Structure and stability of complexes of agmatine with some functional receptor residues of proteins

Remko, Milan; Broer, Ria; Remková, Anna; Duijnen, Piet Th. van

doi:10.1016/j.cplett.2017.02.006

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…The well-studied imidazoline agonist, agmatine (1-amino-4-guanidinobutane, AG) is an endogenous neuromodulator, discovered in the herring semen by Albrecht Kossel in 1910 (Kossel 1910 ). It is synthesized from l -arginine in a reaction catalyzed by arginine decarboxylase (Gawali et al 2017 ; Benitez et al 2018 ; Barua et al 2019 ) which is found in the mitochondria of the cells in the brain, liver, kidneys, adrenal glands, small intestine, and macrophages (Remko et al 2017 ). AG is stored in the granular vesicles in presynaptic terminations and is released into the synaptic cleft after an action potential, where it can act on the receptors or can be degraded (Reis and Regunathan 2000 ; Raasch et al 2001 ; Uzbay 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of imidazoline agents in a rat conditioned place preference model of addiction

Șorodoc

Rusu-Zota

Nechita³

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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Agmatine (AG), idazoxan (IDZ), and efaroxan (EFR) are imidazoline receptor ligands with beneficial effects in central nervous system disorders. The present study aimed to evaluate the interaction between AG, IDZ, and EFR with an opiate, tramadol (TR), in a conditioned place preference (CPP) paradigm. In the experiment, we used five groups with 8 adult male Wistar rats each. During the condition session, on days 2, 4, 6, and 8, the rats received the drugs (saline, or TR, or IDZ and TR, or EFR and TR, or AG and TR) and were placed in their least preferred compartment. On days 1, 3, 5, and 7, the rats received saline in the preferred compartment. In the preconditioning, the preferred compartment was determined. In the postconditioning, the preference for one of the compartments was reevaluated. TR increased the time spent in the non-preferred compartment. AG decreased time spent in the TR-paired compartment. EFR, more than IDZ, reduced the time spent in the TR-paired compartment, but without statistical significance. AG reversed the TR-induced CPP, while EFR and IDZ only decreased the time spent in the TR-paired compartment, without statistical significance.

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