Structure‐based improvement of the binding affinity and recognition specificity of peptide competitors to target pediatric IL‐5R/IL‐5 interaction by gluing halogen bonds at their complex interface
Peipei Chu,
Yeping Sheng,
Chentao Shen
et al.
Abstract:Human interleukin‐5 (IL‐5) cytokine mediates the development of eosinophils and is involved in a variety of immune inflammatory responses that play a major role in the pathogenesis of childhood asthma, leukemia, and other pediatric allergic diseases. The immunomodulatory cytokine functions by binding to its cognate cell surface receptor IL‐5R in a sheet‐by‐sheet manner, which can be conformationally mimicked and competitively disrupted by a double‐stranded cyclic AF18748 peptide. In this study, we systematical… Show more
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