Structure-based prediction of CAD response factors of dammarane-type tetracyclic triterpenoid saponins and its application to the analysis of saponin contents in raw and processed Panax notoginseng

Peng, Ming; Zhang, Tong; Ding, Yue; Yi, Yaxiong; Yang, Yongjian; Jian, Le

doi:10.1039/c6ra03193e

Cited by 12 publications

(8 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20(S)- and 20(R)-Rg 3 are the only pair of C-20 stereoisomers reported in raw P. notoginseng . However, based on our results ( Peng et al, 2016b ), only 20(S)-form stereoisomeric saponins could be found in raw P. notoginseng . Take 20–80 head raw herbs obtained from Yunnan province as an example, 20(S)-notoginsenoside R 1 , 20(S)-Rg 2 and 20(S)-Rh 1 were found, and the amount was in the range of 1.0–1.9, 0.5–1.5, and 0.3–2.1 mg/g, respectively.…”

Section: Chemistrymentioning

confidence: 71%

“…For ELSD and MS detectors, CH 3 COOH and HCOOH are usually added into mobile phases to assist a better volatilization of saponin analytes ( Chan et al, 2007 ; Sun et al, 2009 ; Bae et al, 2013 ; Wan et al, 2013 ). Our group has developed a HPLC-CAD method to simultaneously separate 22 saponins existed in raw and processed notoginseng, in which 5 pairs of 20(S)- and 20(R)-ginsenoside epimers were separated ( Peng et al, 2016b ). In addition, using an appropriate column with small particle size can gain higher efficiency and better isolation.…”

Section: Chemistrymentioning

confidence: 99%

See 1 more Smart Citation

Stereoisomers of Saponins in Panax notoginseng (Sanqi): A Review

Peng

Zhang

et al. 2018

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Panax notoginseng (Sanqi), a traditional Chinese medical drug which has been applied to medical use for over four centuries, contains high content of dammarane-type tetracyclic triterpenoid saponins. A number of stereoisomeric dammarane-type saponins exist in this precious herb, and some are particularly regarded as “biomarkers” in processed notoginseng. Contemporary researches have indicated that some saponin stereoisomers may show stereospecific pharmacological activities, such as anti-tumor, antioxidative, anti-photoaging, anti-inflammatory, antidiabetic, and neuro-protective activities, as well as stereoselective effects on ion channel current regulation, cardiovascular system, and immune system. The current review provides a comprehensive overview of chemical compositions of raw and processed P. notoginseng with a particular emphasis on saponin stereoisomers. Besides, the pharmacological and pharmacokinetic researches, as well as determination and biotechnological preparation methods of stereoisomeric saponins in notoginseng are discussed extensively.

show abstract

Section: Chemistrymentioning

confidence: 71%

Section: Chemistrymentioning

confidence: 99%

Stereoisomers of Saponins in Panax notoginseng (Sanqi): A Review

Peng

Zhang

et al. 2018

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has the effect of good for body to remove heat and calming liver and reducing blood pressure. Some studies have shown that Sanchi flower not only has a significant effect on lowering blood pressure, but also has a small side effect on regulating immune function, promoting NK cell activity and promoting sleep (Peng et al 2016). On May 13, 2016, the health and Family Planning Commission of Yunnan Province officially approved that Sanchi flower and stem leaf can be managed according to common local characteristic food raw materials, and Sanchi flower and stem leaf officially entered the food industry (Zhang et al 2018).. Superfine grinding has emerged as a novel methodology in recent years in processing and development of functional foods.…”

Section: Introductionmentioning

confidence: 99%

Effects of superfine grinding on the physicochemical properties and antioxidant activities of Sanchi (Panax notoginseng) flower powders

Ameer

Jiang

2020

J Food Sci Technol

View full text Add to dashboard Cite

Sanchi flowers were traditionally used as functional medicinal ingredient in materials. The study was aimed at evaluating superfine powder product of Sanchi flower, hence in this study, five fractions of dried Sanchi flower powders (SFP) were prepared at variable particle sizes by superfine grinding and evaluated for changes in various properties. Superfine powder with median particle diameter of 25.57 lm was produced through grinding. It was evident from the environmental scanning electron microscopy analysis that during superfine grinding, mechanical shear stress played its crucial role in breakdown of the SFP and causes increases in surface area owing to reduction of particle sizes. Superfine grinding could improve solubility, oil holding capacity, and brightness, but decrease the fluidity of SFP. SFP with smallest particle size exhibited highest saponin, minerals, total phenolic, and flavonoid contents accompanied with the best antioxidant activities. Size reduction beyond M200 and M400 led to increasing tendency in IR signature band patterns and marked differences in peak intensities while the powdered samples showed resemblance with respect to peak shapes. Differential scanning calorimetry indicated the lowest melting temperature for SFP fraction with smallest particle size. Conclusively, superfine SFP due to inherent improvement in properties may render several potential applications in manufacturing of food and pharmaceutical additives to impart improved functionalities of finally finished products with uniformity.

show abstract

“…Peng et al. [20] developed an HPLC–charged aerosol detector method for the analysis of saponin contents in notoginseng. Among these saponins determined, notoginsenoside R 1 (NG-R 1 ), ginsenoside Rg 1 (G-Rg 1 ), ginsenoside Re (G-Re), ginsenoside Rb 1 (G-Rb 1 ), and ginsenoside Rd (G-Rd) were regarded as the major active constituents [21] .…”

Section: Introductionmentioning

confidence: 99%

Investigating chemical features of Panax notoginseng based on integrating HPLC fingerprinting and determination of multiconstituents by single reference standard

Yang

Zhu

Zhang

et al. 2018

Journal of Ginseng Research

View full text Add to dashboard Cite

BackgroundPanax notoginseng is a highly valued medicine and functional food, whose quality is considered to be influenced by the size, botanical parts, and growth environments.MethodsIn this study, a HPLC method integrating fingerprinting and determination of multiconstituents by single reference standard was established and adopted to investigate the chemical profiles and active constituent contents of 215 notoginseng samples with different sizes, from different botanical parts and geographical regions.ResultsChemical differences among main root, branch root, and rotten root were not distinct, while rhizome and fibrous root could be discriminated from other parts. The notoginseng samples from Wenshan Autonomous Prefecture and cities nearby were similar, whereas samples from cities far away were not. The contents of major active constituents in main root did not correlate with the market price.ConclusionThis study provided comprehensive chemical evidence for the rational usage of different parts, sizes, and growth regions of notoginseng in practice.

show abstract

Structure-based prediction of CAD response factors of dammarane-type tetracyclic triterpenoid saponins and its application to the analysis of saponin contents in raw and processed Panax notoginseng

Abstract: Structure-based impacts of saponins on CAD response factors are discovered, and in-depth analysis of saponins in Panax notoginseng is implemented.

Cited by 12 publications

References 40 publications

Stereoisomers of Saponins in Panax notoginseng (Sanqi): A Review

Stereoisomers of Saponins in Panax notoginseng (Sanqi): A Review

Effects of superfine grinding on the physicochemical properties and antioxidant activities of Sanchi (Panax notoginseng) flower powders

Investigating chemical features of Panax notoginseng based on integrating HPLC fingerprinting and determination of multiconstituents by single reference standard

Contact Info

Product

Resources

About