Structure Determination and Total Synthesis of a Novel Antibacterial Substance, AB0022A, Produced by a Cellular Slime Mold.

Designing inhibitors against fructose 1,6-bisphosphatase: Exploring natural products for novel inhibitor scaffolds

“…However, we found that by substituting solid copper for the copper bronze the yields were substantially improved. Cyclization and the concomitant deprotection of 13 in a 1:1 mixture of HBr and acetic acid [23,24] conveniently yielded 14 as the key intermediate. Next, we were faced with the challenge of functionalizing 14 with the appropriate acyl moiety.…”

Anti-leukemic activities of Dictyostelium secondary metabolites: A novel aromatic metabolite, 4-methyl-5-n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 and HL-60 cells

“…DIF-1 and its analogs possess anti-proliferative activity in mammalian cells (Asahi et al, 1995;Kubohara et al, 1995a,b;Kubohara, 1997;1999;Kubohara and Hosaka, 1999;Miwa et al, 2000;Takahashi-Yanaga et al, 2003;Akaishi et al, 2004;Shimizu et al, 2004). AB0022A (isolated from D. purpureum) possesses antibacterial activities against Gram-positive bacteria (Sawada et al, 2000). DGs (isolated from D. discoideum and D. purpureum) exhibit neurite outgrowth activity in PC12 cells (Kikuchi et al, 2002).…”

“…In addition, DIF-1 has been shown to possess anti-influenza viral activity in vitro (Kuno et al, 2002) and to inhibit progesterone-induced meiosis in Xenopus oocytes . Then, AB0022A, a compound similar to DIF-1, was found in D. purpureum; this compound showed antibacterial activities against Gram-positive bacteria (Sawada et al, 2000). Kikuchi et al (2001Kikuchi et al ( , 2002 have isolated carbohydrate analogs, furanodictines (FDs) (Fig.…”

Natural Products from Social Amoebae

“…Although several compounds involved in the multicellular development of social amoebae have been isolated, AB0022A ( 54 ) (Scheme ) remains the only substance discovered from the social amoebae with antimicrobial activity . Isolated from D. purpureum strain K1001, it was found to selectively inhibit the growth of some Gram‐positive bacteria with minimal inhibitory concentrations (MIC) ranging from 0.40–50 μg mL −1 , whereas selected Gram‐negative bacteria were not inhibited at concentrations of 100 μg mL −1 .…”