Structure elucidation and in vitro reactivity of the major metabolite of 4,4?-methylenebis(2-chloroaniline) (MBOCA) in canine urine*1

Manis, M

doi:10.1016/0272-0590(84)90239-2

Cited by 12 publications

References 22 publications

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4,4′‐Methylen‐bis(2‐chloranilin) [MAK Value Documentation in German language, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 19. Lieferung, Ausgabe 1993 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Angaben zur Pharmakokinetik Bindung an Makromoleküle Erfahrungen beim Menschen Pharmakokinetik Akute Toxizität Subchronische und chronische Toxizität Allergene Wirkung Untersuchungen zur gentoxischen Wirkung Untersuchungen zur kanzerogenen Wirkung Tierexperimentelle Befunde Akute Toxizität Subchronische und chronische Toxizität Allergene Wirkung Reproduktions‐ und Teratogenitätsstudien Untersuchungen zur gentoxischen Wirkung Untersuchungen zur kanzerogenen Wirkung Zur Frage eines MAK‐Wertes

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4,4′‐Methylen‐bis(2‐chloranilin) [MAK Value Documentation in German language, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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4,4′‐Methylenebis(2‐chloroaniline) [MAK Value Documentation, 1996]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 7 (1996) The article contains sections titled: Toxic Effects and Modes of Action Pharmacokinetics Macromolecular binding Effects in Man Pharmacokinetics Acute toxicity Subchronic and chronic toxicity Genotoxicity Carcinogenicity Effects on Animals Acute toxicity Other effects Genotoxicity Carcinogenicity Manifesto (MAK value, classification)

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Biological monitoring of a worker acutely exposed to MBOCA

Osorio

Clapp

Ward

et al. 1990

American J Industrial Med

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A 30 year-old male polyurethane worker was exposed to an accidental spill of 4,4'-methylene-bis-2-chloroaniline (MBOCA) at a plant producing MBOCA-cured plastic products. Exposure to MBOCA is significant in that this compound is a known animal carcinogen and a suspected human carcinogen. The employee was sprayed over his upper body and extremities with molten MBOCA while cleaning out a clogged hose from a MBOCA and polymer mixing machine. The subsequent environmental and medical evaluation of this episode included serial urinary MBOCA samples from the worker over a 2 week period to allow the calculation of a biological half-life for this compound. This worker experienced a very high dose of MBOCA as judged by his urinary MBOCA levels (peak value of 1,700 ppb 4 hours after exposure). There were no acute symptoms or other laboratory abnormalities noted. The kinetic evaluation resulted in a biological half-life for MBOCA in urine of approximately 23 hours. Assuming a one-compartment model, approximately 94% of an initial MBOCA dose will be eliminated within four days. This is the first report of kinetic analysis on urinary MBOCA excretion in humans. This information suggests that biological monitoring of the urine MBOCA concentrations in exposed workers may miss peak levels following an acute exposure unless the analyses of the urinary MBOCA are performed in a timely fashion. Recommendations to the company included: 1) installation of a warning system or lock-out device on the mixing machine to prevent the opening of the MBOCA hose prior to the release of pressure; and 2) annual medical surveillance of this individual for bladder cancer with urinalysis and urine cytology.

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Structure elucidation and in vitro reactivity of the major metabolite of 4,4?-methylenebis(2-chloroaniline) (MBOCA) in canine urine*1

Cited by 12 publications

References 22 publications

4,4′‐Methylen‐bis(2‐chloranilin) [MAK Value Documentation in German language, 1993]

4,4′‐Methylen‐bis(2‐chloranilin) [MAK Value Documentation in German language, 1993]

4,4′‐Methylenebis(2‐chloroaniline) [MAK Value Documentation, 1996]

Biological monitoring of a worker acutely exposed to MBOCA

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