2019
DOI: 10.1016/j.fct.2019.110827
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Structure-function and application of plant lectins in disease biology and immunity

Abstract: A B S T R A C TLectins are proteins with a high degree of stereospecificity to recognize various sugar structures and form reversible linkages upon interaction with glyco-conjugate complexes. These are abundantly found in plants, animals and many other species and are known to agglutinate various blood groups of erythrocytes. Further, due to the unique carbohydrate recognition property, lectins have been extensively used in many biological functions that make use of protein-carbohydrate recognition like detect… Show more

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Cited by 154 publications
(102 citation statements)
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References 283 publications
(304 reference statements)
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“…Lectins, or hemagglutinins, are a diverse family of carbohydrate-binding proteins found in almost all organisms, including plants, animals, and microorganisms [ 14 ]. These proteins/glycoproteins possess the unique capability to reversibly bind to specific carbohydrate moieties on cells, resulting in erythrocyte agglutination.…”
Section: Lectinsmentioning
confidence: 99%
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“…Lectins, or hemagglutinins, are a diverse family of carbohydrate-binding proteins found in almost all organisms, including plants, animals, and microorganisms [ 14 ]. These proteins/glycoproteins possess the unique capability to reversibly bind to specific carbohydrate moieties on cells, resulting in erythrocyte agglutination.…”
Section: Lectinsmentioning
confidence: 99%
“…The carbohydrate specificity of lectins allows them to function in cell recognition, tissue development, host defense and tumor metastasis in both plants and animals [ 15 , 16 ]. Over 500 lectins have been isolated and identified from plants, who produce them primarily as defense mechanisms against insects, molds, fungi and diseases [ 14 ].…”
Section: Lectinsmentioning
confidence: 99%
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“…After conjugation with a bacterial exotoxin, a remarkable cytotoxicity was observed in several patient-derived models, suggesting excellent tumor penetration. Most importantly, the authors excluded that rBC2LC-N caused human serum agglutination in vitro, which is a frequently observed phenomenon after lectin administration [ 115 ]. These results not only pave the way for a potential imaging strategy for PDAC, but also provide a novel explorable approach for glycan targeting.…”
Section: Glycansmentioning
confidence: 99%
“…Lectinas são proteínas ou glicoproteínas naturais, derivadas de plantas ou animais, ligantes de açúcares (MISHRA, et al, 2019). De modo geral, as associações entre lectinas e glicanos são essenciais na regulação de interações entre células, entre células e componentes da matriz extracelular, bem como entre células e patógenos (THAN et al, 2015).…”
Section: Galectinaunclassified