2023
DOI: 10.32604/biocell.2023.030233
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Structure, function, and mechanism of the TNFAIP8 (TIPE) family of proteins in cancer and inflammation

ZIPENG LIN,
CHUXI TANG,
LE KANG
et al.

Abstract: The multiple roles of the tumor necrosis factor (TNF)-α-inducible protein 8 (TNFAIP8), also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis. In this review, we found that the TIPE family showed highly homologous sequences and conserved functional domains, such as the death effector domain (DED)-like domain but displayed different roles and mechanisms in different biological activities. For example, while TIPE is primarily as… Show more

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