Structure investigation of solid ion pairs of three imidazole drugs-Rose Bengal using different spectroscopic techniques and Their Biological Activities

Abstract

T HE present work is concerned with preparation, separation and structure elucidation of solid ion-pairs of three antifungal drugs Fluconazole (FLZ), Voriconazole (VRZ) and Butoconazole nitrate (BTZ) with Rose Bengal (Rbeng). The solid ion-pairs were prepared and investigated using FT-IR, mass spectral (MS) and thermal analyses (TA), in addition to elemental analysis (EA). The general formulae of the prepared ion-pairs were determined. Moreover, the formulae of prepared ion-pairs were proposed and structurally identified. The biological activities of the separated solid ion-pairs towards five types of bacteria and one type fungi in comparison with their drugs were studied, and they were found to be biologically active more than their parent drugs.

Novel p-nitrophenyl Maleanilic Acid and Its Organometallic Chelates of Cr, Mo and W Carbonyls Structure Evaluation Using Different Techniques and Chromium Chelate Cytotoxicity

“…The results of the MTT assay of [Cr(CO) 4 L] complex clarified that the free ligand inhibitory potency was slightly decreased by the complexation with Cr(CO) 6 . These results were explained in the same way like that previously published [44][45][46] in research our group.…”

Synthesis, physico‐chemical characterization and theoretical exploration of some 2,4,5‐triaryl imidazole derivatives

“…This five member organic heterocyclic scaffolds not only finds applications in biological and medicinal field but also finds many applications in analytical and industrial fields [3]. Substituted imidazole derivatives have remarkable binding affinity with various metal ions present in numerous biological active sites and also found to exhibit good inhibitory activities against glucagon receptor antagonists [4], P38 MAP kinaseinhibitors [5], B-Raf kinaseinhibitors [6], etc. (Figure 1).…”

Insight into the Inclusion Complexation of Fluconazole with Sulfonatocalix[4]naphthalene in Aqueous Solution, Solid-State, and Its Antimycotic Activity

“…Moreover, the low aqueous solubility of the drug could affect its bioavailability and therapeutic performance [ 34 ]. Different research groups reported many complexation studies of the FZ with varying types of naturally occurring and semisynthetic macrocyclic cyclodextrins [ 38 , 48 , 55 , 56 , 57 , 58 ]. Abranches et al [ 34 ] reported a complexation study of FZ with sodium p -sulfonatocalix[ n ]arenes ( n = 4 and 6).…”

“…Different research groups reported many complexation studies of the FZ with varying types of naturally occurring and semisynthetic macrocyclic cyclodextrins [38,48,[55][56][57][58]. Abranches et al [34] reported a complexation study of FZ with sodium p-sulfonatocalix[n]arenes (n = 4 and 6).…”