Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction

Abstract

Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives were synthesized through the esterification of the hydroxyl group of quinine. The reaction with various alkyl and aryl carbonyl chloride resulted in the series of ester quinine derivatives. The structure of quinine derivatives was characterized by IR, melting point, UV, 1H NMR, 13C NMR, LCMS.

Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments

“…Currently, quinine and its derivatives are considered as potential treatments for COVID-19 [ 8 , 9 , 10 , 11 ]. Taking into account the high potential activity, numerous studies are underway in the world aimed at searching for new drugs among quinine derivatives, including the esterification reaction of the C-9 hydroxyl group [ 12 , 13 , 14 , 15 ].…”