Structure modulation on fluorescent probes for biothiols and the reversible imaging of glutathione in living cells

Liu, Yu; Chen, Li; Zhu, Yan; Chen, Liming; Li, Junbo; Chen, Dugang

doi:10.1039/d1ra03221f

Cited by 4 publications

(2 citation statements)

References 55 publications

(59 reference statements)

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“…For example, the lack of l -cys causes immune system weakness, liver damage, and skin lesions, while its excess causes neurological disorders . Likewise, an excess of Homocys in blood plasma (5–15 μM) mainly results in pathological disorders, Alzheimer’s disease, and premature diabetic retinopathy. , On the other hand, an imbalance in l -gluta is known to cause a wide range of proliferative diseases including cancer, neurodegenerative disorders, cystic fibrosis (CF), and HIV. , Hence, developing a highly sensitive method to competently detect these biothiols over multiple platforms is highly demanding. Common biosensory platforms include radioimmunoassay, polymerase chain reaction (PCR), electrochemical sensors, and lateral flow immunoassay, which suffer from anti-interfering recognition and low detection limit.…”

Section: Introductionmentioning

confidence: 99%

“…22,23 On the other hand, an imbalance in L-gluta is known to cause a wide range of proliferative diseases including cancer, neurodegenerative disorders, cystic fibrosis (CF), and HIV. 24,25 Hence, developing a highly sensitive method to competently detect these biothiols over multiple platforms is highly demanding. Common biosensory platforms include radioimmunoassay, polymerase chain reaction (PCR), electrochemical sensors, and lateral flow immunoassay, which suffer from anti-interfering recognition and low detection limit.…”

Section: ■ Introductionmentioning

confidence: 99%

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Brønsted Acid-Functionalized Ionic Co(II) Framework: A Tailored Vessel for Electrocatalytic Oxygen Evolution and Size-Exclusive Optical Speciation of Biothiols

Goswami

Karthick

Das

et al. 2022

ACS Appl. Mater. Interfaces

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Metal−organic frameworks (MOFs) not only combine globally demanded renewable energy generation and environmental remediation onto a single platform but also rationalize structure−performance synergies to devise smarter materials with remarkable performance. The robust and non-interpenetrated cationic MOF exemplifies a unique bifunctional scaffold for the efficient electrochemical oxygen evolution reaction (OER) and ultrasensitive monitoring of biohazards. The microporous framework containing Brønsted acidfunctionalized [Co 2 (μ 2 -OH)(CO 2 ) 2 ] secondary building units (SBUs) exhibits remarkable OER performance in 1 M KOH, requiring 410 mV overpotential to obtain 10 mA cm −2 anodic current density, and a low Tafel slope of 55 mV/dec with 93.1% Faradaic efficiency. Apart from the high turnover frequency and electrochemically assessable surface area, steady OER performance over 500 cycles under potentiodynamic and potentiostatic conditions result in long-term catalyst durability. The highly emissive attribute from nitrogen-rich fluorescent struts benefits the MOF in recyclable and selective fluoro-detection of three biothiols (L-cysteine, homocysteine, and glutathione) in water with a fast response time. In addition to colorimetric monitoring in the solid and solution phases, control experiments validate size-exclusive biothiol speciation through molecular-dimension-mediated pore diffusion. The role of SBUs in the OER mechanism is detailed from density functional theory-derived free energy analysis, which also validates the importance of accessible N-sites in sensing via portraying framework−analyte supramolecular interactions.

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