Structure, organization and expression of common carp (Cyprinus carpio L.) NKEF-B gene

Labeo rohitaandArgulus siamensisinfection: Host size, local inflammatory reaction and immunity modulate ectoparasite load on fish

“…NKEF was up‐regulated in all infected samples as compared to control. It was earlier observed that this gene was up‐regulated in response to LPS, viral and parasitic infections (Bethke et al., ; Chen, Wu, Niu, Shi & Li, ; Chen et al., ; Cuesta & Tafalla, ; Dong, Xiang & Shao, ; Huang, Gao, Wang, Hu & Guo, ; Loo, Sutton & Schuller, ; Ordás, Cuesta, Mercado, Bols & Tafalla, ; Pérez‐Sánchez, Bermejo‐Nogales, Calduch‐Giner, Kaushik & Sitjà‐Bobadilla, ; Utke et al., ). The transcript level was high in infected samples because it has role in inflammatory response, tissue repair by protecting cells from oxidative stress after infection and protection against cell death (Bethke et al., ; Ishii, Warabi & Yanagawa, ).…”

Viral hemorrhagic septicaemia virus (VHSV) up-regulates the cytotoxic activity and the perforin/granzyme pathway in the rainbow trout RTS11 cell line

“…In fish, although there is only few data available concerning the granule-dependent pathways with PRF and GRZ, the involvement of these two proteins in cytotoxic activities has been established [43,44]. Furthermore, at the gene level, PRF1 but not PRF2 nor PRF3 were up-regulated in crucian carp CTLs from allo-sensitized fish [17] whilst the GRZ gene was up-regulated in common carp after viral infection [28]. Further studies are still needed to ascertain the exact role of these proteins in the cytotoxic activities of rainbow trout monocyte/macrophages.…”

Identification and characterization of common carp (Cyprinus carpio L.) granzyme A/K, a cytotoxic cell granule-associated serine protease

“…Noteworthily, BR-C Z4, FOXD3, Elk-1 and HNF-1 have been found in human GzmK promoter, and BR-C Z4, HLF and CDP CR1 have been found in human GzmA promoter. While, CDP CR1, BR-C Z4, Pax-6, Elk-1, FOXD3 and HNF-1 have also been reported in carp NKEF-B promoter [48]. This seems that carp NKEF-B and GzmA/K gene may be regulated by the same system and cooperate to play their role in carp immune system.…”