Structures and Bioactivities of Steroidal Saponins Isolated from the Genera Dracaena and Sansevieria

Thu, Zaw Min; Oo, Sann Myint; Nwe, Thinn Myat; Aung, Hnin Thanda; Armijos, Chabaco; Hussain, Faiq H. S.; Vidari, Giovanni

doi:10.3390/molecules26071916

Cited by 18 publications

(19 citation statements)

References 75 publications

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“…One of the plants known to be traditionally used to treat alopecia is Sansevieria trifasciata Prain [ 32 ]. This plant has several bioactive compounds such as alkaloids, flavonoids, steroids, terpenoids, and tannins [ 33 , 34 ]. In previous studies, linoleic acid in Sansevieria trifasciata Prain can interact with 5α-reductase receptors to prevent alopecia by prolonging the anagen phase of hair growth [ 10 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Unrevealing the Potential of Sansevieria trifasciata Prain Fraction for the Treatment of Androgenetic Alopecia by Inhibiting Androgen Receptors Based on LC-MS/MS Analysis, and In-Silico Studies

et al. 2022

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Androgenetic Alopecia (AGA) occurs due to over-response to androgens causing severe hair loss on the scalp, and requires the development of new and efficient drugs to treat this condition. This study explores and identifies secondary metabolites from Sansevieriatrifasciata Prain using the LC-MS/MS and in-silico method. The inhibitory activity of bioactive compounds from S. trifasciata Prain against androgen receptors (PDB ID: 4K7A) was evaluated molecularly using docking and dynamics studies by comparing their binding energies, interactions, and stability with minoxidil. The results of the LC-MS/MS analysis identified Methyl pyrophaeophorbide A (1), Oliveramine (2), (2S)-3′, 4′-Methylenedioxy-5, 7-dimethoxyflavane (3), 1-Acetyl-β-carboline (4), Digiprolactone (5), Trichosanic acid (6) and Methyl gallate (7) from the leaves subfraction of this plant. Three alkaloid compounds (compounds 1, 3, and 4), and one flavonoid (compound 2), had lower docking scores of −7.0, −5.8, −5.2, and −6.3 kcal/mol, respectively. The prediction of binding energy using the MM-PBSA approach ensured that the potency of the four compounds was better than minoxidil, with energies of −66.13, −59.36, −40.39, and −40.25 kJ/mol for compounds 1, 3, 2, and 4, respectively. The dynamics simulation shows the stability of compound 1 based on the trajectory analysis for the 100 ns simulation. This research succeeded in identifying the compound and assessing the anti-alopecia activity of Sansevieria trifasciata Prain. Seven compounds were identified as new compounds never reported in Sansevieria trifasciata Prain. Four compounds were predicted to have better anti-alopecia activity than minoxidil in inhibiting androgen receptors through an in silico approach.

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Section: Introductionmentioning

confidence: 99%

Unrevealing the Potential of Sansevieria trifasciata Prain Fraction for the Treatment of Androgenetic Alopecia by Inhibiting Androgen Receptors Based on LC-MS/MS Analysis, and In-Silico Studies

et al. 2022

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“…Fourteen spirostane, cholestane, furostane and stigmastane steroidal saponins types were detected in the phytoconstituent profile of DRSE. Spirostane and furostane steroidal saponins are the predominant saponin classes in the Dracaena genus (Thu et al, 2021).…”

Section: Steroidal Saponinsmentioning

confidence: 99%

“…Dragon's blood is a non-specific name for reddish resinous products, usually used in traditional medicine as granules, powder, lumps or sticks. It is obtained by cutting the stems of various plants belonging to four distinct plant genera: Croton (Euphorbiaceae), Dracaena (Dracaenaceae), Daemonorops (Palmaceae) and Pterocarpus (Fabaceae) (Gupta et al, 2008;Thu et al, 2021). Dragon's blood was obtained originally from Dracaena cinnabari, later from Dracaena draco and more recently from Daemonorops (Mabberley, 2017).…”

Section: Introductionmentioning

confidence: 99%

In vitro wound healing properties, antioxidant activities, HPLC–ESI–MS/MS profile and phytoconstituents of the stem aqueous methanolic extract of Dracaena reflexa Lam

Raslan

Afifi

2022

Biomedical Chromatography

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Column chromatography of the stem aqueous methanolic extract of Dracaena reflexa Lam. (DRSE) led to the isolation of five flavonoids, one phenolic glycoside, one triterpenoid and two steroidal saponins. Furthermore, 44 compounds were tentatively identified in the phytoconstituent profile of DRSE using HPLC-ESI-MS/MS. The antioxidant activity of DRSE was evaluated. In a DPPH radical scavenging assay, DRSE exhibited an IC 50 value of 311.6 ± 10.10 μg/ml compared with the IC 50 value of the standard Trolox (24.42 ± 0.87 μg/ml). The antioxidant activities of DRSE using ABTS assay and ferric reducing antioxidant power assay were 326.63 μM Trolox equivalents/mg extract and 208.67 μM Trolox equivalents/mg extract, respectively.The wound-healing activity of DRSE was studied by the scratch assay using Human Skin Fibroblast cells. After 24 h DRSE (at 10 and 20 μg/ml) decreased the wound width to 0.55 ± 0.37 and 0.47 ± 0.55 mm, respectively, compared with the wound width in the control cells (0.77 ± 0.17 mm). This result suggested that DRSE improved the wound-healing process by inducing the migration of fibroblasts.Moreover, a docking study was performed to evaluate the binding affinity of the identified phytoconstituents toward GSK-3β relative to the co-crystalized inhibitor and curcumin with the possible involvement of this pathway in the wound-healing activity of the extract.

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“…The genus Dracaena consists of more than 100 accepted species which are mainly distributed in the tropics and subtropics, especially in Africa, Australia, and Southern Asia (Thu et al, 2020(Thu et al, , 2021. They are mainly succulent shrubs and trees, and a few are commonly grown as shrubby houseplants, especially the variegated forms (Thu et al, 2020).…”

mentioning

confidence: 99%

“…Leaves and rhizomes of these plants are used in folk medicine for treating asthma, cough, sexual weakness, hypertension, diarrhea, hemorrhoids, abdominal pains, colics, eczema, piles, edema, jaundice, anuria, palpitations, viral hepatitis, malaria, snake-and insect bites, etc. (Andhare et al, 2012;Kpodar et al, 2016;Giovannini and Howes, 2017;Thu et al, 2021). Besides the medicinal aspects, several Dracaena species have great horticultural importance and are commercialized for use in landscaping and as indoor ornamental plants (Lekawatana and Suwannamek, 2017).…”

mentioning

confidence: 99%

Lipid Peroxidation and Total Antioxidant Capacity in the Muscle Tissue of Atlantic Sturgeon (Acipenser oxyrinchus oxyrinchus Mitchill) after In Vitro Treatment by Extracts Derived from Various Species of Dracaena Genus (Asparagaceae Juss.)

Tkachenko

2022

Agrobiodivers Improv Nutr health life Qual

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Water extracts from selected Dracaena plants cultivated in greenhouse conditions were evaluated for antioxidant properties by in vitro methods using the muscle tissue of Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus Mitchill). The level of 2-thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) in the muscle tissue of Atlantic sturgeon after treatment in vitro by extracts derived from leaves of selected Dracaena plants (in final concentration 10 mg.mL -1 ) were assessed. When muscle tissue was incubated with leaf extracts of various species belonging to the Dracaena genus, the TBARS level was significantly increased for the sixteen extracts studied. Moreover, all extracts (except D. singularis extract) increase the formation of TBARS in the extracts-treated muscle tissue, and these results were statistically significant. Treatment of muscle tissue by extracts derived from various species from the Dracaena genus revealed also increase the TAC level. When homogenates were incubated with leaf extracts derived from various species from the Dracaena genus, the TAC level was significantly increased for the fifteen extracts studied. Moreover, all extracts (except D. hyacinthoides and D. roxburghiana extracts) induced the TAC increase in the extracts-treated muscle tissue of Atlantic sturgeon, and these increases were statistically significant. It can be supposed that secondary plant metabolites, i.e. polyphenolic compounds, alkaloids, flavonoids, saponins, glycosides, terpenoids, tannins, etc., in extracts derived from the leaves of various species belonging to the Dracaena genus, may contribute to their antioxidant activity. Further detailed studies on the effect of extracts derived from leaves of selected Dracaena plants on long time intervals, antioxidant, and molecular aspects are necessary to understand the mechanism of action of extracts in other fish and animals.

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Structures and Bioactivities of Steroidal Saponins Isolated from the Genera Dracaena and Sansevieria

Cited by 18 publications

References 75 publications

Unrevealing the Potential of Sansevieria trifasciata Prain Fraction for the Treatment of Androgenetic Alopecia by Inhibiting Androgen Receptors Based on LC-MS/MS Analysis, and In-Silico Studies

Unrevealing the Potential of Sansevieria trifasciata Prain Fraction for the Treatment of Androgenetic Alopecia by Inhibiting Androgen Receptors Based on LC-MS/MS Analysis, and In-Silico Studies

In vitro wound healing properties, antioxidant activities, HPLC–ESI–MS/MS profile and phytoconstituents of the stem aqueous methanolic extract of Dracaena reflexa Lam

Lipid Peroxidation and Total Antioxidant Capacity in the Muscle Tissue of Atlantic Sturgeon (Acipenser oxyrinchus oxyrinchus Mitchill) after In Vitro Treatment by Extracts Derived from Various Species of Dracaena Genus (Asparagaceae Juss.)

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