Structures posterior to the olfactory bulb which are responsible for the mouse killing and hyperreactivity following lesions of the olfactory bulb

Albert, D.J.; Nanji, N.; Chew, Grace

doi:10.1016/0031-9384(81)90165-7

Cited by 18 publications

(7 citation statements)

References 21 publications

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“…The killing frequencies obtained in the gentled and lesioned animals are comparable to the highest frequencies we have obtained with such lesions (Albert & Brayley, 1979) . The killing frequencies of the nongentled groups are slightly lower than those we have obtained with another experiment (Albert , Nanji, & Chew, 1981).…”

Section: Discussioncontrasting

confidence: 77%

“…Reactivity to the experimenter was tested on Day 2 in the manner described in several recent reports (Albert & Brayley, 1979;Albert & Richmond , 1975 ;Albert, Nanji, & Chew, 1981).…”

Section: Methodsmentioning

confidence: 99%

“…The significance of gentling as a variable was suggested when we noticed that the frequency of killing obtained in an experiment in which the rats had inadvertently received a small amount of handling preoperatively (Albert & Brayley, 1979) was substantially higher than that obtained in another experiment in which they did not (Albert, Nanji, & Chew, 1981 …”

mentioning

confidence: 99%

“…Mouse killing can be induced by brain lesions, but again, the success rate varies considerably even in animals in which the lesions are similar (Albert & Brayley, 1979;Albert, Nanji, & Chew, 1981;Ec1ancher & Karli, 1980;Malick, 1970 ;Panksepp, 1971). Although a considerable amount of this variation may be the result of some differences in the size, shape, and location of lesions, these do not account for all of the behavioral variation.…”

mentioning

confidence: 99%

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Enhancement of lesion-induced mouse killing by preoperative gentling

Albert

Chew

Tobani

et al. 1981

Bull. Psychon. Soc.

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Rats that did not spontaneously kill mice were either gentled or not gentled for 10 min/day for 7 days. Animals from both the gentled and nongentled groups were then subjected to a lesion of the lateral septum, a lesion ventral to the anterior septum, or a sham lesion. When tested at 48 h postoperatively, the frequency of killing in the gentled groups was 70% to 90% for lesioned animals, about double that in the ungentled lesion groups . There was no effect of gentling on killing by the unlesioned groups, both of which had less than 15% killers. The relationship of the facilitation of mouse killing caused by gentling to a decrease of fear is discussed .

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Section: Discussioncontrasting

confidence: 77%

“…Reactivity to the experimenter was tested on Day 2 in the manner described in several recent reports (Albert & Brayley, 1979;Albert & Richmond , 1975 ;Albert, Nanji, & Chew, 1981).…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Enhancement of lesion-induced mouse killing by preoperative gentling

Albert

Chew

Tobani

et al. 1981

Bull. Psychon. Soc.

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“…Although irritability has been noted in a number of studies on OBX rats (Cain & Paxinos, 1974; van Riezen et al, 1977), other investigators have failed to observe it (Cain, 1974a; Thorne, Aaron, & Latham, 1974). It has been suggested by Cain (1974b) and Albert, Nanji, and Chew (1981) that a contributing factor to this inconsistency is the variability in the size of the lesion made when removing the olfactory bulbs. The latter investigators suggested that the increased reactivity sometimes seen with olfactory bulb lesions results from incidental damage to the region ventral to the anterior septum.…”

Section: Discussionmentioning

confidence: 99%

Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham-operated rats.

Jesberger¹,

Richardson²

1986

Behavioral Neuroscience

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Removal of the main olfactory bulbs in rats has been shown to alter neuronal function in brain areas involved in emotional regulation and homeostasis. These neuronal alterations result in maladaptive behavioral patterns and elevated plasma corticosterone that are suggestive of the symptom profile of patients with primary unipolar depression. Moreover, the endocrine and behavioral deficits of bulbectomized rats are reversed by the chronic administration of drugs that reverse the symptoms of depression in people when given chronically. However, the therapeutic improvements seen in patients with depression are not directly due to molecules of the antidepressant drug but rather to some relatively long-lasting compensatory change induced in the neuronal substrate by the drug. The present research demonstrates that the reversal of the olfactory bulb lesion deficits following chronic antidepressant drug administration in rats is not due to molecules of the drug per se but rather to some drug-induced change in the neuronal substrate that continues for at least 5 days after the last dose of drug. These endocrine, behavioral, and pharmacological similarities suggest that the study of rats with olfactory bulb ablation may make significant contributions to the understanding of the neuroscience of primary unipolar depression in humans.

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