Studies directed towards the total synthesis of pentacyclic terpenoids, by Austin M. Greaves.

Greaves, A.J.

doi:10.22215/etd/1980-00468

Cited by 21 publications

(28 citation statements)

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“…The content of the effective component of candida antigen may be not enough to release histamine from leucocytes in vitro at the concentrations used in the present experiments. Another explanation for this is that house dust or candida antigens may be not suitable for reaction with IgE antibodies on the basophils for release of histamine, because of the abnormal distribution of IgE on the cells in chronic urticaria, as speculated by Greaves, et al (12). In addition, the leucocytes of some patients may respond poorly to the antigenantibody reaction on the cell surface, even when the leucocytes are sensitized (13).…”

Section: Discussionmentioning

confidence: 99%

The Role of Mite, House Dust and Candida Allergens in Chronic Urticaria

Numata

Yamamoto

Yamura

1980

The Journal of Dermatology

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Intradermal skin tests and in vitro antigen‐induced histamine release from leucocytes were carried out using mite, house dust and candida allergens in 49 patients with chronic urticaria in whom the cause was not identifiable from the history. None of them had other atopic diseases. Among the 49 cases, the number of patients who gave positive skin reactions to different allergens was as follows: mite, 24; house dust, 18; candida, 17. Significant histamine release from leucocytes by mite antigen was observed in 8 out of 12 patients who had 2+ or 3+ skin reactions. The present results suggest that mite, house dust and candida allergens may play a role in chronic urticaria, and especially that the mite may be one of the possible allergens in chronic urticaria.

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Section: Discussionmentioning

confidence: 99%

The Role of Mite, House Dust and Candida Allergens in Chronic Urticaria

Numata

Yamamoto

Yamura

1980

The Journal of Dermatology

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“…Our findings that IgG suppresses priming are analogous to some reports [3. 33] but at variance with others [13,23,31,34]. In two of the latter reports [23,34], in which IgG enhanced the priming, soluble antigens were used.…”

Section: Discussionmentioning

confidence: 99%

Specific IgM Enhances and IgG Inhibits the Induction of Immunological Memory in Mice

Heyman

Wigzell

1985

Scand J Immunol

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The effect of priming mice with IgM anti-SRBC (sheep erythrocytes) together with SRBC or IgG anti-SRBC together with SRBC on the development and expression of memory cells was studied. Mice primed with specific IgM and SRBC showed a much more efficient secondary plaque-forming cell and serum antibody response after challenge with SRBC in an adoptive transfer system than did controls primed with SRBC only. The expression of this enhanced memory of IgM-primed spleen cells was counteracted by the high levels of internal IgG anti-SRBC (also the result of priming with IgM) when the mice, instead of being tested in adoptive transfers, were challenged directly. The antigen-specific feedback suppression of the primary antibody response by specific IgG antibodies was also seen to inhibit partially the development of memory cells. The suppressive effect on priming could be demonstrated both in adoptive transfer systems and after direct boost of the same mice that received the primary immunization. Both the IgM enhancement and the IgG suppression of memory cell development were antigen-specific, since no effect on the antibody response to a non-cross-reacting antigen, horse erythrocytes, was seen. The effect of these up- or down-regulations of immunological memory could be demonstrated after secondary injections as long as 90-280 days after priming.

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“…In diesem Zusammenhang könnte die Immunreaktion des Wirtes mit nativen oder denaturierten autologen, bzw. exogenen kreuzreagierenden Antigenen, aber auch der Verlust von T-ZellSuppression mit Auftreten von autoreaktiven B-Zellen im Alter eine Rolle spielen (60).…”

Section: Diskussionunclassified

Bestimmung von Serum Fcγ-Antiglobulinen bei Patienten mit chronischer Polyarthritis und systemischem Lupus erythematodes mit einem Enzymimmunotest (ELISA)

Fink¹,

Peiler²,

Deicher³

1983

LaboratoriumsMedizin

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Erythematosus by . Serum Fcy-antiglobulins were measured by use of a sandwhich antibody type ELISA. As solid phase antigen served Fey-material. It was obtained after papain cleavage of human IgG and combined affinity-and gel chromatography using Protein A-Sepharose CL-4B "and Sephadex G-150 columns. Serum Fcy-antiglobulins bound to the coated solid phase were detected photometrically by peroxidase-labelled rabbit anti-human-kappa I light chain antibodies. In sera from 29 patients with seropositive and 20 patients with seronegative rheumatoid arthritis (RA) significantly (p< 0.0005) increased serum Fcy-antiglobulin. levels compared to 41 healthy blood donors were found. No significant (p > 0.1) difference with regard to the amount of serum F.cy-antiglobulins was observed between the two RA-subgroups. Compared to the reference range sera from 19 patients with systemic lupus erythematosus (SLE) contained to a major extent no Fcy-antiglobulins.Â weak correlation was noticed between serum Fcy-antiglobulins and l g M-rheumatoid factor titers for patients with RA (r: 0.82) and SLE (r:,0.79). Neither for RA patients nor for SLE patients a correlation was found between serum Fcy-antiglobulins and antinuclear factors, anti-DNS-antibodies, circulating immune complexes and total t^aemolytic complement (CH50) activity.

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Studies directed towards the total synthesis of pentacyclic terpenoids, by Austin M. Greaves.

Cited by 21 publications

References 0 publications

The Role of Mite, House Dust and Candida Allergens in Chronic Urticaria

The Role of Mite, House Dust and Candida Allergens in Chronic Urticaria

Specific IgM Enhances and IgG Inhibits the Induction of Immunological Memory in Mice

Bestimmung von Serum Fcγ-Antiglobulinen bei Patienten mit chronischer Polyarthritis und systemischem Lupus erythematodes mit einem Enzymimmunotest (ELISA)

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