Studies in Calcium Metabolism. Effect of Food Phytates on Calcium45 Uptake in Children on Low-Calcium Breakfasts

Bronner, Felix; Harris, Robert S.; Maletskos, C.J.; Benda, Clemens E.

doi:10.1093/jn/54.4.523

Cited by 45 publications

(28 citation statements)

References 14 publications

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“…Analysis for calcium was carried out by a modification (Bronner, Harris, Maletskos & Benda, 1954) of the method of Salomon, Gabrio & Smith (1946). In general, urine and all plasma samples were wet-ashed with a 1:1 mixture of HN03-HC104 before analysis; only very dilute urine samples could be analysed directly by precipitation of the calcium with oxalate.…”

Section: F Bronner and D D Thompsonmentioning

confidence: 99%

Renal transtubular flux of electrolytes in dogs with special reference to calcium

Bronner¹,

Thompson²

1961

The Journal of Physiology

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Section: F Bronner and D D Thompsonmentioning

confidence: 99%

Renal transtubular flux of electrolytes in dogs with special reference to calcium

Bronner¹,

Thompson²

1961

The Journal of Physiology

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“…Reducing the dietary content of inositol phosphates, absorption of minerals, like iron, zinc and calcium increases (McCance & Widdowson, 1942a;Bronner et al 1954;Nävert et al, 1985;Sandström et al 1987a, b;Kivistö et al, 1989;Heaney et al 1991;Weaver et al 1991Weaver et al , 1993Brune et al, 1992;Larsson et al, 1996). Dietary phytase from untreated cereals seems to be an important factor for phytate hydrolysis in humans, whereas intestinal phytase does not seem to play a significant role in phytate hydrolysis in man (Kivistö et al, 1986;Sandberg et al, 1987;Sandberg & Andersson, 1988).…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal treatment and malting of barley improved zinc absorption but not calcium absorption in humans

et al. 2003

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Objective: To study whether hydrothermal treatment or malting of barley (cv. Blenheim) improves zinc and calcium absorption in humans. Design: Two groups of 10 and 12 healthy subjects, respectively, were in a period of 2 months in a fasting state, served two single meals each containing porridge or breakfast cereals prepared from processed or unprocessed (control) barley (60 g). The meals included 200 g of milk, extrinsically labelled with 65 Zn and 47 Ca. Whole-body retention of both minerals was measured. Setting: The study was carried out at the Department of Radiation Physics, Sahlgrenska University Hospital, Göteborg. Subjects: The subjects were recruited among students at the Göteborg University. None dropped out. Interventions: The activities of 65 Zn and 47 Ca were measured by whole-body counting four to five times over a 4-week period after each meal. Results: Zinc absorption from hydrothermally treated barley porridge, containing 28 mg P as inositol tri-to hexaphosphates (InsP 3 -InsP 6 ), was significantly higher (Po0.001) than from control porridge containing 111 mg P as InsP 3 -InsP 6 , 25.276.9 vs 11.072.5% (n ¼ 12). Calcium absorption did not differ (P40.05), 21.176.8 vs 19.574.7% (n ¼ 12). Zinc absorption from breakfast cereals of malted barley with phytase activity and containing 70 mg P as InsP 3 -InsP 6, was significantly higher (Po0.05) than from flakes of barley, containing 108 mg P as InsP 3 -InsP 6 and no phytase activity, 22.975.8 vs 14.874.6% (n ¼ 10). The calcium absorption was 21.376.5 vs 18.574.3% (n ¼ 10) and did not differ significantly (P40.05).

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“…The dissected long bones were roentgenographed. Samples were analyzed for Ca45, total Ca, moisture, and ash content by the methods outlined by Bronner, and co-workers (8,19). The data were statistically analyzed, when possible, by methods explained in Snedecor (20); SD in this paper refers to "standard deviation.…”

Section: Methodsmentioning

confidence: 99%

“…The serum data in Figures 1 to 3 indicate that most of the Ca45 taken either intravenously or enterally entered the calcium depots within 1 week. Bronner and coworkers (8) have suggested that studies of the uptake, retention, and excretion of Ca45 administered by various routes and in various carriers may be completed within 10 days.…”

Section: Methodsmentioning

confidence: 99%

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Calcium Metabolism of the Normal Rhesus Monkey*

Harris¹,

Moor²,

Wanner³

1961

J. Clin. Invest.

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In research related to human nutrition, it has become a tradition first to conduct extensive studies on one or more species of experimental animal, and then to attempt to confirm the findings from these studies on relatively small groups of human beings. It is important that the animal species selected for study should closely resemble the human being with respect to the absorption, metabolism, degradation, and excretion of the nutrient under study. The species acceptable for the study of one nutrient is not necessarily the species of choice for the study of a different nutrient.The rat and the dog have been used extensively in nutrition studies. These species appear to metabolize many nutrients in a manner similar to that of human beings, but Wanner and co-workers (1) presented preliminary data indicating that neither of these species is a satisfactory substitute for human beings in studies of calcium metabolism. They injected trace amounts of Ca45 intravenously, and observed that the ratio of Ca45 excretion in the urine and feces during the next 5 days was 1: 22 in the rat, 1: 10 in the dog, 2: 1 in the monkey, and 2: 1 in the human being. It has since been reported by Bronner, Harris, Maletskos and Benda (2) that the urine: feces excretion ratios of six young human subjects ranged from 0.50: 1 to 3.2: 1 and averaged 1.9: 1. To our knowledge there are no other reports of similar studies on physiologically normal human subjects. Data obtained on patients with carcinoma, multiple myeloma, and thyroid disorders indicate that the excretion of Ca45 is disturbed in these situations, for the urine: feces excretion

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Studies in Calcium Metabolism. Effect of Food Phytates on Calcium45 Uptake in Children on Low-Calcium Breakfasts

Cited by 45 publications

References 14 publications

Renal transtubular flux of electrolytes in dogs with special reference to calcium

Renal transtubular flux of electrolytes in dogs with special reference to calcium

Hydrothermal treatment and malting of barley improved zinc absorption but not calcium absorption in humans

Calcium Metabolism of the Normal Rhesus Monkey*

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