Studies of Fusospirochetal Infection: 1. Pathogenicity for Guinea Pigs of Individual and Combined Cultures of Spirochetes and Other Anaerobic Bacteria Derived from the Human Mouth

Rosebury, Theodor; Clark, Ada R.; Engel, Sylvia G.; Tergis, Frances

doi:10.1093/infdis/87.3.217

Cited by 35 publications

(11 citation statements)

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“…Human bacterial plaque has demonstrated pathogenic potential when implanted into extraoral sites such as subcutaneous destructive abscesses in humans (54,164) or in experimental animals (50,(204)(205)(206)227). A number of toxic products can be detected in dental plaque, including endotoxins (96,166,167), cell wall mucopeptides (2231( , fatty and organic acids (141, 144, 239, 240, 257, 2681( , H,S (151, 187, 201, 253), NH, (150, 202, 257), indole (151, 2391 and leukotoxin (7,159).…”

Section: Pathogenic Potential Of Plaque Bacteriamentioning

confidence: 99%

Evidence of bacterial etiology: a historical perspective

Socransky

Haffajee²

1994

Periodontology 2000

308

234

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Section: Pathogenic Potential Of Plaque Bacteriamentioning

confidence: 99%

Evidence of bacterial etiology: a historical perspective

Socransky

Haffajee²

1994

Periodontology 2000

308

234

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“…Polymicrobial infections involving black-pigmented Gram-negative anaerobes are likely to have a greater pathogenic potential than infections with a single species. The successful transmission of infections in animals that were given defined mixtures of aerobic and anaerobic organisms has established the key role of 'Bacteroides melaninogenicus' in these synergic infections [13]. Pr.…”

Section: Virulencementioning

confidence: 99%

Interactions between black-pigmented Gram-negative anaerobes and other species which may be important in disease development

Gharbia

Shah

1993

FEMS Immunology &Amp; Medical Microbiology

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“…Vincent's infection.-Rosebury et al (95,96,97) have carried out studies to determine the part played by the components of the bacterial mixture found associated with fusospirochetal infections. Fifteen anaerobic bacteria isolated from various sources, and including spirochetes, fusobacteria, vibri os, streptococci, a Bacteroides, and a presumptive Leptotrichia, were inocu lated subcutaneously into guinea pigs individually and in various combina tions (95).…”

Section: Bacterial Associations In Oral Infectionsmentioning

confidence: 99%

“…Fifteen anaerobic bacteria isolated from various sources, and including spirochetes, fusobacteria, vibri os, streptococci, a Bacteroides, and a presumptive Leptotrichia, were inocu lated subcutaneously into guinea pigs individually and in various combina tions (95). In no case was it possible to reproduce the lesions obtained with exudate from Vincent's infection.…”

Section: Bacterial Associations In Oral Infectionsmentioning

confidence: 99%

Oral Microbiology

Hoffman¹

1957

Annu. Rev. Microbiol.

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The leading theme of this review, microbial ecology of the mouth, has been so fully developed in recent years that only oblique reference is possible to the problem of dental caries, which at present is the central concern of den tal research. Fortunately, however, several bibliographies, reviews and sym posia are available (5,26,82,108,116,120) which are reasonably up-to-date. The present survey is primarily concerned with the literature since Harri son's review of 1949 (39); even so, limitations of space make it impossible to report on all of the significant studies which have appeared. QUALITATIVE STUDIES OF THE ORAL FLORAFrom the University of Birmingham has come an intensive qualitativ e study by Morris (72 to 77) of most of the oral flora in seven carious and fou r caries immune subjects which contributes significantly to our knowledge o f oral ecology. The kinds of microorganisms identified from cultures of mouth rinses and gingival scrapings were as follows: alpha, beta, and gamma strepto cocci, enterococci, corynebacteria, actinomycetes, fusobacteria, gram-nega tive bacilli, lactobacilli, Hemophilus, Leptotrichia, Nocardia, Streptomyces, Veillonella, Neisseria, micrococci, and pneumococci. The viruses, protozoa, spirochetes and yeasts were not studied. Morris (77) found a considerable difference between the types of organisms observed by early workers in the oral cavity and those organisms found in healthy mouths today, apparently attributable to improved oral hygiene in recent years. From Morris' study the bacterial flora of the mouth appeared to consist in a greater degree of specialized oral parasites than had previously been believed.Several microorganisms have been reported for the first time as mem bers of the oral flora. Morton et aZ. (81) have detected pleuropneumonia-like organisms in the saliva of 46 persons out of 100 examined, while a subse quent study (80) of a smaller group gave an even higher incidence. These are the first reports of the organisms being present in high incidence in a region of the human body outside of the genito-urinary tract. Throat cultures yielded a lower percentage of pleuropneumonia-like organisms [Smith & Mor ton (114)] than mouth cultures, but as was the case for the mouth, the inci dence was higher in the throat than for the normal female [Randall et aZ. (91); Klieneberger-Nobel (56)] and male [Beveridge et aZ. (10)] genito-urinary tracts. Dienes & Madoff (22) were able to obtain abundant growth of pleuro pneumonia-like organisms from debris between the teeth and from material 1 The survey of literature pertaining to this review was completed in August, 1956. 183 Annu. Rev. Microbiol. 1957.11:183-198. Downloaded from www.annualreviews.org Access provided by Northwestern University -Evanston Campus on 02/07/15. For personal use only.Quick links to online content Further ANNUAL REVIEWS

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Studies of Fusospirochetal Infection: 1. Pathogenicity for Guinea Pigs of Individual and Combined Cultures of Spirochetes and Other Anaerobic Bacteria Derived from the Human Mouth

Cited by 35 publications

References 0 publications

Evidence of bacterial etiology: a historical perspective

Evidence of bacterial etiology: a historical perspective

Interactions between black-pigmented Gram-negative anaerobes and other species which may be important in disease development

Oral Microbiology

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