Studies of Pig Complement: Measurement of Pig CH50, ACH50, and Components

Sakai, Rieko; Kitano, Etsuko; Hatanaka, Minoru; Lo, Pei‐Chi; Matsuura, Ryohei; Deguchi, Kenji; Eguchi, Hidetoshi; Maeda, Akira; Watanabe, Masaru; Matsunari, Hitomi; Nagashima, Hiroshi; Okuyama, Hiroomi; Miyagawa, Shuji

doi:10.1016/j.transproceed.2015.10.066

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Considering the important roles of complement system in the innate immunity, there is limited understanding as to whether complement activation by nanoparticles in preclinical species can resemble human response. For instance pigs have considerably lower levels of complement factors and lower activity of all complement pathways in comparison to humans [ 91 , 93 ]. This raises significant concern in using the porcine model to investigate, for instance, the involvement of complement in hypersensitivity reactions.…”

Section: Complement Responses To Nanomaterials Nanopharmaceuticals An...mentioning

confidence: 99%

“…Towards resolving the role of complement anaphylatoxins in infusion reactions, we have not been able to inhibit complement in pigs in vivo, since availability of porcine-specific complement inhibitors and C3 knockout pigs are scarce [ 112 , 113 ]. Notwithstanding, considering differences between porcine and human complement functionality [ 91 ], we should further await studies with complement therapeutics (e.g., complement inhibitors of different steps of the complement cascade either approved by regulatory bodies or in clinical development) [ 114 – 116 ] to evaluate and dissect the role of complement cascade in nanomedicine-mediated infusion reactions in humans.…”

Section: Infusion Reactions To Nanoparticles and Nanopharmaceuticalsmentioning

confidence: 99%

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Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions

Moghimi

Haroon

Yaghmur

et al. 2023

Journal of Controlled Release

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Section: Complement Responses To Nanomaterials Nanopharmaceuticals An...mentioning

confidence: 99%

Section: Infusion Reactions To Nanoparticles and Nanopharmaceuticalsmentioning

confidence: 99%

Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions

Moghimi

Haroon

Yaghmur

et al. 2023

Journal of Controlled Release

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“…According to Maye [ 33 ] the bactericidal activity in bovine milk is higher than in human milk. Similarly, Sakai [ 34 ] detected a lower complement activity in porcine sera compared to human sera. Each of the above mentioned authors used a different method of complement activity determination, so itis incomparable in absolute numbers.…”

Section: Discussionmentioning

confidence: 99%

The impact of parturition induction with cloprostenol on immunological parameters in the sow colostrum

2020

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Background Farrowing induction with prostaglandin F2 analogue cloprostenol is commonly used on commercial farms to manage the timing of farrowing. When labour induction is applied, the questions arise about possible side effects of such a hormonal intervention on physiological processes connected with labour and lactation, including colostral immunity. Results In this study, immune cells composition, lysozyme concentration, complement bacteriolytic activity and proinflamatory (GM-CSF2, IL-1β, IL-6, a TNFα) and anti-inflammatory (IL-4, IL-10, TGFβ1 a TGFβ2) cytokines were measured in colostrum samples from sows farrowing naturally (NP) and from sows with farrowing induced using cloprostenol administration on day 113 of gestation (IP). A significantly higher proportion of lymphocytes was found in colostrum of induced sows compared to colostrum of non-induced sows. No significant differences between NP and IP were found in complement activity, in the proportions of granulocytes, macrophages and lymphocyte subpopulations. Lower lysozyme concentration and higher IL-1β, IL-6, TGFβ1 and TNFα concentrations were found in IP sow colostrum compared to colostrum from NP sows. Conclusions An increased proportion of colostral lymphocytes can positively influence the cellular immunity transmission from sow to her offspring. On the other hand, a lower lysozyme concentration can adversely affect newborn’s intestinal immunity, as well as changes in cytokine concentrations can have an adverse effect on newborn piglet intestinal epithelium development and its defence function.

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“…According to Maye [29] the bactericidal activity in bovine milk is higher than in human milk. Similarly, Sakai [30] detected a lower complement activity in porcine sera compared to human sera. Each of the above mentioned authors used a different method of complement activity determination, so itis incomparable in absolute numbers.…”

Section: Cytokines Concentrationsmentioning

confidence: 93%

The Impact of Parturition Induction With Cloprostenol on Immunological Parameters in the Sow Colostrum

Hlavová¹,

Kudláčková²,

Faldyna³

2020

Preprint

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Background: Farrowing induction with prostaglandin F2 analogue cloprostenol is commonly used on commercial farms to manage the timing of farrowing. When labour induction is applied, the questions arise about possible side effects of such a hormonal intervention on physiological processes connected with labour and lactation, including colostral immunity.Results: In this study, immune cells composition, lysozyme concentration, complement bacteriolytic activity and proinflamatory (GM-CSF2, IL-1β, IL-6, a TNFα) and anti-inflammatory (IL-4, IL-10, TGFβ1 a TGFβ2) cytokines were measured in colostrum samples from sows farrowing naturally (NP) and from sows with farrowing induced using cloprostenol administration on day 113 of gestation (IP). A significantly higher proportion of lymphocytes was found in colostrum of induced sows compared to colostrum of non-induced sows. No significant differences between NP and IP were found in complement activity, in the proportions of granulocytes, macrophages and lymphocyte subpopulations. Lower lysozyme concentration and higher IL-1β, IL-6, TGFβ1 and TNFα concentrations were found in IP sow colostrum compared to colostrum from NP sows. Conclusions: An increased number of colostral lymphocytes can positively influence the cellular immunity transmission from sow to her offspring. On the other hand, a lower lysozyme concentration can adversely affect newborn’s intestinal immunity, as well as changes in cytokine concentrations can have an adverse effect on newborn piglet intestinal epithelium development and its defence function.

show abstract

Studies of Pig Complement: Measurement of Pig CH50, ACH50, and Components

Cited by 6 publications

References 5 publications

Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions

Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions

The impact of parturition induction with cloprostenol on immunological parameters in the sow colostrum

The Impact of Parturition Induction With Cloprostenol on Immunological Parameters in the Sow Colostrum

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