Studies of Skin Reactions to Propylene Glycol1

Warshaw, Thelma G.; Herrmann, F.

doi:10.1038/jid.1952.118

Cited by 59 publications

(9 citation statements)

References 5 publications

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“…Two patients in our series demonstrated a threshold sensitivity because they only reacted to a higher concentration of propylene glycol. This concept is evident in previous patch test studies, [6][7][8][9] in which increasing concentrations of propylene glycol are less well tolerated. Paradigms for elicitation thresholds for allergic and irritant contact dermatitis have been described.…”

Section: Selected Case Reportsmentioning

confidence: 80%

Allergic contact dermatitis to topical minoxidil solution: Etiology and treatment

Friedman

Cohen

et al. 2002

Journal of the American Academy of Dermatology

169

103

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Section: Selected Case Reportsmentioning

confidence: 80%

Allergic contact dermatitis to topical minoxidil solution: Etiology and treatment

Friedman

Cohen

et al. 2002

Journal of the American Academy of Dermatology

169

103

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“…Propylene glycol (1,2‐propanediol) is a common humectant found in pharmaceutical and cosmetic bases, which occasionally causes contact allergy (1). The potential for sensitization and irritant reactions to propylene glycol has been recognized since 1952, when Warshaw and Herrmann (2) reported reactions in patients in whom it was used as a solvent for patch test allergens. It has been proposed that reactions to propylene glycol may be classified as irritant or allergic contact dermatitis, non‐immunological contact urticaria and sensory irritation (3).…”

Section: Discussionmentioning

confidence: 99%

Contact dermatitis from propylene glycol in ECG electrodes, complicated by medicament allergy

Connolly

Buckley

2004

Contact Dermatitis

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“…The allergenic properties of propylene glycol were found in the early 1950s (21) and established in the late 1960s and 1970s (22)(23)(24)(25). The optimal concentration of propylene glycol for patch testing has been a matter of controversy.…”

Section: Discussionmentioning

confidence: 99%

The repeated open application test (ROAT)

1986

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Repeated open application tests (ROATs) were performed with common ingredients of vehicles in 86 patients with contact dermatitis. The substances were applied twice daily for 7 days to the flexor aspect of the forearm near the cubital fossa, unless dermatitis appeared earlier. Of the patients with a questionable (?+) patch test result, 44% were positive in ROATs. The corresponding figure was 80% in the patients with a positive (+ or ++) response in the patch test, when the results of ROAT with propylene glycol were excluded. Only 5 of 14 patients reacting to 30% or to 10% propylene glycol but not to 1% in water in patch testing, showed a positive result to a cream containing 5% propylene glycol in ROAT. All 5 patients with a positive patch test reaction to 1% propylene glycol reacted to 5% propylene glycol in ROAT. The results suggest that ROATs should be performed more often, especially in patients in whom little known or new allergens are suspected as being the cause of allergic contact dermatitis.

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Studies of Skin Reactions to Propylene Glycol1

Cited by 59 publications

References 5 publications

Allergic contact dermatitis to topical minoxidil solution: Etiology and treatment

Allergic contact dermatitis to topical minoxidil solution: Etiology and treatment

Contact dermatitis from propylene glycol in ECG electrodes, complicated by medicament allergy

The repeated open application test (ROAT)

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