Studies on a Second Long-Acting Fluphenazine

Simpson, George M.; Amin, Muhammad; Kunz, E; McCafferty, Frank

doi:10.1176/ajp.121.8.784

Cited by 15 publications

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“…A s mentioned fluphenazine was the first neuroleptic introduced on the markets in the USA and Europe as a depot preparation, and in the USA it is still the only marketed depot preparation (274,275).…”

Section: Fluphenazine Esters In Sesame Oilmentioning

confidence: 99%

Chemotherapy With Neuroleptics

Knudsen

1985

Acta Psychiatr Scand

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Attempting to improve long-term neuroleptic treatment of schizophrenic patients several injectable depot neuroleptics have been developed. Moreover pharmacokinetic data increasingly have been clinically applied. On this background the purpose of the present paper has been to make an updated review of the clinical and pharmacokinetic knowledge of depot neuroleptic treatment.First, general aspects of antipsychotics have been summarized, and an outline of methodological questions relevant to clinical-pharmacological trials are given. Subsequently general aspects including pros & cons of depot administration are examined. Finally the available data of the various depot preparations have been scrutinized.It is concluded that our present pharmacokinetic knowledge of the particular depot preparations is incomplete. Thus more information of clinical relevant aspects are needed, e.g., the existence of a therapeutic range, maximumiminimum concentration ratio, and the significance of active metabolites.Comparing the various depot neuroleptics, no significant differences are seen regarding the clinical effects. However, the decanoate esters seem clinical superior to the corresponding enanthate esters explained by the more flat concentration curve of the decanoates.Apart from that, a comparison of the pharmacokinetic data is difficult because of the heterogenecy of the available data.Haloperidol, clopenthixol and perphenazine decanoates are among the best examined preparations in pharmacokinetic respects. A controlled double-blind comparative study of these preparations would be of interest.

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Section: Fluphenazine Esters In Sesame Oilmentioning

confidence: 99%

Chemotherapy With Neuroleptics

Knudsen

1985

Acta Psychiatr Scand

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“…It was also shown to be only slightly less effective than chlorpromazine (Lasky et al, 1962). Many studies indicate that it is effective in the treatment of schizophrenia and in maintaining schizophrenic patients in the community (Simpson et al, 1965;Kurland & Richardson, 1966;Neal & Imlah, 1970).…”

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confidence: 99%