Studies on aculeacin. I. Isolation and characterization of aculeacin A.

Abstract

Aculeacin A, a new antifungal antibiotic was isolated from the mycelial cake of Aspergillus aculeatus M-4214. The antibiotic is a white amorphous powder soluble in lower alcohols and hardly soluble in other organic solvents or water. Aculeacin A gave palmitic acid and five ninhydrin-positive products including threonine, hydroxyproline upon acid hydrolysis. The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity.

FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738

“…These compounds belong to the echinocandin family, a class of antifungal agents that act on the fungal cell wall by inhibiting glucan synthesis. The members of the echinocandin family of fungal origin are FR901379 [14,15], echinocandin B [16], aclueacins [17], mulundocandin [18] and pneumocandins [19], which are produced by C. empetri No. 11899, Aspergillus nidulans, A. aculeatus, A. sydowi and Glarea lozoyensis, respectively.…”

Compounds active against cell walls of medically important fungi

“…Similarly, aculeacins A to D and F to G have good in vitro activity against Candida spp. and S. cerevisiae and inhibitory though not lethal activity against several filamentous fungi (167,168,211).…”

“…The aculeacins, echinocandins, and papulacandins were all discovered as fermentation metabolites during screening programs for new antibiotics. The aculeacins, isolated from Aspergillus aculeatus, were described in 1977 as a complex of seven lipoprotein compounds: aculeacins A, B, C, D, E, F, and G (168,211). Aculeacin A (Fig.…”

FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573

“…These compounds have similar structures to FR901379 [3,4], the points of difference having different amino acid constituents compared to FR901379 and, most strikingly, a sulphate residue presenting at a different position of the aryl ring. Other related antifungal lipopeptides of fungal origin are FR901379 [3,4], echinocandin B [5] aculeacins [6], mulundocandin [7] and pneumocandins [8,9], which are produced by Coleophoma empetri No. 11899, A. nidulans, A. aculeatus, A. sydowi and Glarea lozoyensis, respectively.…”