Studies on Aldosterone Responsiveness to Angiotensin II during Clinical Variations in Calcium Metabolism in Normal Man

Bianchetti, Mario G.; Beretta-Piccoli, C; Weidmann, P; Boehringer, K; Link, L; Morton, J. J.

doi:10.1042/cs0630325

Cited by 19 publications

(6 citation statements)

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“…In this study, the intravenous infusion of nicardipine did not interfere with the aldosterone response. There is no conclusive evidence that long-term therapy with nifedipine inhibits the aldosterone response (Bianchetti et al, 1982;Millar et al, 1983); similarly, in this study, therapy with nicardipine for 1 week had no significant effect on the aldosterone response. It has been shown that aldosterone levels were low relative to the level of plasma renin activity during chronic therapy with nifedipine (Hiramatsu et al, 1982), but this was not confirmed in the present study with nicardipine.…”

Section: Discussioncontrasting

confidence: 71%

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Effects of nicardipine on aldosterone release and pressor mechanisms.

Elliott¹,

Pasanisi²,

Reid³

1985

Brit J Clinical Pharma

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This study evaluated the effects of nicardipine, following intravenous infusion and oral administration, on the pressor and aldosterone responses to infused angiotensin II. Six healthy, normotensive male subjects were studied. Following administration of nicardipine, no significant change in blood pressure was seen. Nicardipine attenuated the pressor response produced by intravenous administration of angiotensin. Nicardipine did not inhibit the aldosterone response to angiotensin.

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Section: Discussioncontrasting

confidence: 71%

“…However, there is evidence that nifedipine acutely diminished the aldosterone response to angiotensin II (Millar et al, 1981;Vierhapper & Waldhausl, 1982). This inhibition was not sustained during chronic therapy (Bianchetti et al, 1982;Millar et al, 1983).…”

Section: Methodsmentioning

confidence: 99%

Effects of nicardipine on aldosterone release and pressor mechanisms.

Elliott¹,

Pasanisi²,

Reid³

1985

Brit J Clinical Pharma

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“…In agreement with the previous study [29], our study shows that plasma renin activity and aldosterone levels remain unchanged after dosing with nifedipine-SR. Aldosterone synthesis in the zona glomerulosa is stimulated by angiotensin (ANG II), and nifedipine-C diminishes the response to exogenous ANG II when given acutely [30,31] but not chronically [32,33]. However, aldosterone levels during chronic administration of nifedipine-C are less than what would be expected from concurrent values for circulating renin [34].…”

Section: Discussionmentioning

confidence: 86%

Administration of slow-release nifedipine does not affect lactate threshold, hormone release during exercise, and quality of life in normal subjects

Handa

Mori

Tanaka

et al. 1992

Cardiovasc Drug Ther

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In a double-blind crossover study of 10 normal healthy subjects, we examined the effects of slow-release nifedipine (nifedipine-SR, 10 mg b.i.d) administration on exercise capacity, hormone levels during exercise, and quality of life (QOL) after a 2-week treatment. Two exercise tests, a progressive exercise test and a constant work-rate exercise test, were performed. Maximal oxygen uptake (VO2max) and blood lactate concentration were measured during the progressive exercise test and the exercise intensity corresponding to half lactate threshold (LT), LT, and 4 mmol/l of lactate concentration was determined. Subjects underwent 20 minutes of constant work-rate exercise at each work load, and blood lactate, plasma epinephrine, plasma norepinephrine, plasma renin activity, plasma aldosterone, atrial natriuretic peptide, plasma beta-endorphin, and met-enkephalin were measured. Taking nifedipine-SR had no effect on the responses of blood pressure, heart rate, VO2max, maximal work load, and LT compared to taking placebo. Blood lactate, plasma catecholamine, plasma renin activity, aldosterone, atrial natriuretic peptide, and beta-endorphin levels increased during exercise, and there was no difference between nifedipine-SR and placebo. Met-enkephalin did not increase with either treatment. In the QOL questionnaires, no differences were noted between the two treatments. These findings suggest nifedipine-SR to be a potentially useful drug in view of the lack of effect on exercise capacity, hormone release, and QOL.

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“…In contrast, Marone et al (1981) did not observe any significant change in plasma aldosterone in response to an acute hyper¬ calcaemia. In a further study (Bianchetti et al 1982), the same group reported that mild hyper¬ calcaemia induced by calcium gluconate infusion did not influence aldosterone responsiveness to angiotensin II. The sum of these partially conflict¬ ing results does not allow a firm conclusion on the influence of calcium on aldosterone secretion.…”

Section: Discussionmentioning

confidence: 95%

Effects of an acute calcium load on plasma ACTH, cortisol, aldosterone and renin activity in man

Isaac

Raymond

Rainfray

et al. 1984

Acta Endocrinologica

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Plasma adrenocorticotrophin (ACTH), cortisol and aldosterone increased during and after iv administration of calcium gluconate in 4 normal subjects, one patient with hypoparathyroidism and one patient with hypothyroidism. On the other hand, there was a decrease in plasma renin activity but only in the normal subjects.Plasma ACTH and cortisol responses to calcium were abolished whereas plasma aldosterone response persisted in 2 normal subjects pre-treated with dexamethasone.The results observed after calcium administration were compared to those observed after infusion of the solvent only in 6 normal subjects and 4 thyroidectomized patients who were studied twice at 3 day intervals. Plasma ACTH, cortisol and aldosterone were higher when calcium was administered. Plasma renin activity was not statistically different whether or not calcium had been injected in the subjects studied twice. These results demonstrate a direct effect of calcium on ACTH and aldosterone secretion which is not mediated by calcitonin and parathyroid hormone. The stimulatory effect of calcium on cortisol secretion depends on the increase in plasma ACTH.

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Studies on Aldosterone Responsiveness to Angiotensin II during Clinical Variations in Calcium Metabolism in Normal Man

Cited by 19 publications

References 0 publications

Effects of nicardipine on aldosterone release and pressor mechanisms.

Effects of nicardipine on aldosterone release and pressor mechanisms.

Administration of slow-release nifedipine does not affect lactate threshold, hormone release during exercise, and quality of life in normal subjects

Effects of an acute calcium load on plasma ACTH, cortisol, aldosterone and renin activity in man

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