Studies on an antitumor polysaccharide RBS derived from rice bran. II. Preparation and general properties of RON, an active fraction of RBS.

Takeo, Suguru; Kado, Hisao; Yamamoto, Hisao; Kamimura, Minoru; Watanabe, Nobuhiro; Uchida, Kiichi; Mori, Yoshitada

doi:10.1248/cpb.36.3609

Cited by 29 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The result described here in the Apc Min mouse is consistent with reports on the effect of rye bran (10% in the diet administered for 5 -6 weeks, Mutanen et al, 2000) and wheat bran (5 -20% for 7 -9 weeks, Hioki et al, 1997;Yu et al, 2001), which have previously been shown to reduce adenoma development in this model. Molecules in the rice bran fibre fraction, which may have contributed to inhibition of adenoma formation observed here in the Apc Min mouse, are the carbohydrates dextran-like a-glucan and arabinoxylan hemicellulose, both of which have previously been suggested to possess cancer chemopreventive properties (Takeo et al, 1988;Takenaka and Takahashi, 1991;Aoe et al, 1993). In principle there are three types of mechanism by which dietary fibre is thought to interfere with colorectal carcinogenesis (for review, see Young et al, 2005), and they may also be germane to rice bran fibre.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis

et al. 2007

View full text Add to dashboard Cite

Brown rice is a staple dietary constituent in Asia, whereas rice consumed in the Western world is generally white, obtained from brown rice by removal of the bran. We tested the hypothesis that rice bran interferes with development of tumours in TAg, TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) or Apc Min mice, genetic models of mammary, prostate and intestinal carcinogenesis, respectively. Mice received rice bran (30%) in AIN-93G diet throughout their post-weaning lifespan. In TAg and TRAMP mice, rice bran did not affect carcinoma development. In TRAMP or wild-type C57Bl6/J mice, dietary rice bran increased kidney weight by 18 and 20%, respectively. Consumption of rice bran reduced numbers of intestinal adenomas in Apc Min mice by 51% (Po0.01), compared to mice on control diet. In parallel, dietary rice bran decreased intestinal haemorrhage in these mice, as reflected by increased haematocrit. At 10% in the diet, rice bran did not significantly retard Apc Min adenoma development. Likewise, low-fibre rice bran (30% in the diet) did not affect intestinal carcinogenesis, suggesting that the fibrous constituents of the bran mediate chemopreventive efficacy. The results suggest that rice bran might be beneficially evaluated as a putative chemopreventive intervention in humans with intestinal polyps.

show abstract

Section: Discussionmentioning

confidence: 92%

Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Modified arabinoxylan extracted from rice bran has been shown to enhance the activity of natural killer cells after oral intake of modified rice bran (MNG‐3) in man (Ghoneum 1998). α‐Glucan extracted from rice bran by ethanol has potent antitumour activity (Takeo et al 1988), whereas various polysaccharides belonging to β‐glucan from mushroom, such as Lentinus , Schizophyllum and Grifola , are resposible for the antitumour effects (Borchers et al 1999).…”

mentioning

confidence: 99%

Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin

Endo

Kanbayashi

2003

Pharmacology & Toxicology

View full text Add to dashboard Cite

“…For example, polysaccharides in water extracts of rice bran enhanced TNF-α production of mouse macrophages [18]. A previous report indicated that water soluble polysaccharides from rice bran caused antitumor effects in animal model experiments [19]. Some phenolic compounds including f lavonoids or phenolic acids are known.…”

Section: Discussionmentioning

confidence: 99%

Potent Immunomodulating Effects of Bran Extracts of Traditional Japanese Millets on Nitric Oxide and Cytokine Production of Macrophages (RAW264.7) Induced by Lipopolysaccharide

Hosoda

Okai

Kasahara

et al. 2012

J UOEH

View full text Add to dashboard Cite

: To estimate the potent immunomodulating effects of different types of traditional Japanese millet, we analyzed the effect of bran extracts of foxtail millet (Awa in Japanese), barnyard millet (Hie) and proso millet (Mochi-kibi) on nitric oxide (NO) and inf lammatory cytokine production induced by lipopolysaccharide (LPS) in a mouse macrophage cell line (RAW264.7 cells). All methanol extracts of these millet brans showed suppressive activities against the production of NO and inf lammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and Interleukin (IL)-6 in LPS-stimulated macrophages, which were not responsible for their cytotoxic activities. These immunosuppressive activities were roughly proportional to the contents of the phenolic compounds in their extracts. Especially, the extract of proso millet exhibited the strongest immunosuppressing effect, which was associated with the highest content of phenolic compound. However, the extracts did not exhibit significant suppressive effects on the production of an anti-inf lammatory cytokine, IL-10, in the same macrophage culture system. These results suggest that traditional Japanese millets have potent immunomodulating activities against the production of NO and cytokine production in activated macrophages.

show abstract

Studies on an antitumor polysaccharide RBS derived from rice bran. II. Preparation and general properties of RON, an active fraction of RBS.

Cited by 29 publications

References 0 publications

Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis

Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis

Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin

Potent Immunomodulating Effects of Bran Extracts of Traditional Japanese Millets on Nitric Oxide and Cytokine Production of Macrophages (RAW264.7) Induced by Lipopolysaccharide

Contact Info

Product

Resources

About