Studies on Anti Typhoid Properties of Aqueous Methanol Leaves Extract of Albizia ferruginea (Musase)

Sarkiyayi, S.

doi:10.9734/ijbcrr/2011/167

Cited by 5 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of these saponins have been reported to have cytotoxic activity on different cell lines, which highlights the importance of performing more in-depth studies in order to know the mechanism of the cytotoxic activity of these saponins and the structure activity relationship. Also, many extracts of different species of genus Albizia have been reported to have many pharmacological activities, such as antimicrobial activity of A. ferrugenia [9] and A.lebbeck [10], Antidiabetic activity of A.odoratissima [11], and anti-depressant activity of A. julibrissin [12].Therefore, further studies are required to determine whether these pharmacological activities are attributed to saponins or not [13][14][15][16][17][18][19][20][21][22].…”

Section: Melek Et Al [18]mentioning

confidence: 99%

Saponins from Genus Albizia: Phytochemical and Biological Review

D¹

2015

Med Aromat Plants

View full text Add to dashboard Cite

Pharmacological activities of extracts containing saponins from different Albizia species Anti-inflammatory activity: The aqueous ethanolic extract of A. amara roots exhibited significant anti-inflammatory effect in rats at dose of 200 mg/kg administrated compared to the standard dose of aspirin (100 mg/kg). The anti-inflammatory effect was evaluated using carrageenan-induced paw oedema where the percentage inhibition of oedema was 61.91% [2]. The aqueous ethanolic extract of A. lebbeck bark showed significant anti-inflammatory effect at dose of 400 mg/kg administrated to rats compared to the standard dose of indomethacin (10 mg/kg).The antiinflammatory effect was evaluated using carrageenan, dextran, and cotton pellet-induced paw oedema where the percentage inhibition of oedema was 59.57%, 52.93%, and 53.57%, respectively [3]. Analgesic activity: The aqueous ethanolic extract of A. amara roots showed analgesic effect at dose of 200 mg/kg administrated to rats compared to the standard dose of aspirin (100 mg/kg). The analgesic effect was evaluated using hot plate method test [2]. The aqueous and ethanolic extracts of A. lebbeck leaves revealed analgesic effect at doses of 50, 100, and 200 mg/kg administrated to rats. The analgesic effect was evaluated using the hot plate test and tail flick method [4]. Nootropic and anxiolytic activity: The n-butanolic fraction of the methanolic extract of A. lebbeck leaves showed nootropic and anxiolytic activity at dose of 25 mg/kg administrated to albino mice. This effect was evaluated using the elevated plus maze test [5]. Anti-histaminic activity: The ethanolic extract of A. lebbeck stem bark inhibited histamine signaling in sensitized rats at a dose of 200 mg/ rat through suppression of H1 receptors and histidine decarboxylase genes (HDC) transcriptions [6]. Anti-microbial activity: The 70% aqueous ethanolic extract of A. ferruginea stem bark and leaves showed antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Aspergillus niger, and Penicillium notatum. The anti-microbial activity was evaluated by calculating zone of inhibition were the leaves extract was more active and P. aeruginosa was resistant to both extracts [7]. Anti-spermatogenic activity: Oral administration of 50 mg/kg of a saponin-rich fraction obtained from the A. lebbeck stem bark for 60 days to male rats led to decrease in the weights of testes, epididymides, seminal vesicle and ventral prostate also the production of round spermatid was reduced by 73.04% [8]. Pharmacological activity wasn't only evaluated on extracts containing saponins, but it was also evaluated on pure isolated saponins. Table 1 and Figures 1-7 shows

show abstract

Section: Melek Et Al [18]mentioning

confidence: 99%

Saponins from Genus Albizia: Phytochemical and Biological Review

D¹

2015

Med Aromat Plants

View full text Add to dashboard Cite

show abstract

“…Although there are many methods to prepare it, boiling it in water and letting it cool before eating is a common method. Before consuming the herbal mixture, the patient may breathe in the steam as an alternate form of treatment (Sarkiyayi and Abdul Rasheed, 2013). Therefore, the goal of our research is to evaluate and screen the phytochemicals in A. nilotica fruit's aqueous extract for potential antiproliferative activity, which has historically been utilized in Nigeria to treat cancer and other ailments.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening, antiproliferative evaluation, and molecular docking studies of Acacia nilotica fruit from Nigeria

Anthony,

Okpala,

Obiyenwa

et al. 2024

Eclet. Quim.

View full text Add to dashboard Cite

Acacia nilotica, (Fabaceae), is valued for its medicinal properties. We examine the antiproliferative properties of the aqueous fruit extract of A. nilotica. Aqueous extract from Acacia has been associated with potential anticancer effects in fruits and vegetables through screening, antiproliferative, and molecular docking evaluation. Phytochemical screening reveals the presence of alkaloids, saponins, tannins, flavonoids, steroids, and carbohydrates. The extracts showed significant antiproliferative effects at eight concentrations (8�50 mg�mL�1) examined in comparison to the standard (methotrexate). When compared to Sorghum bicolor seed radicles treated with methotrexate at 48, 72, and 96 h, 50 mg�mL�1 extract significantly inhibited the generation of seed radicals, with potent inhibitions of 87.06, 83.48, and 81.45%. Analysis of molecular docking results showed that [(2R,3S)-2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-3,4-dihydro-2H-chromen-7-yl]3,4,5-trihydroxybenzoate (D21), (5R,9R,10R,13S,14S,17S)-17-[(2S,4R)-4-[(2S)-3,3-dimethyloxiran-2-yl]-4-hydroxybutan-2-yl]-4,4,10,13,14-pentamethyl-1,2,5,6,9,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-3-one (D28) and [(2R,3S)-2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-3,4-dihydro-2H-chromen-5-yl] 3,4,5-trihydroxybenzoate (D29) have strong tendency to inhibit dihydrofolate reductase (1VDR), capase-9 (6J15) and Mycobacterium tuberculosis (Mtb) (6J17) better than methotrexate and azacitidine, known antiproliferative drugs. These findings support the use of A. nilotica in traditional medicine for the treatment of tuberculosis and cancer.

show abstract

“…Worldwide, it has many uses including control of pests such as pathogenic microorganisms (Agyare et al, 2006;Sarkiyiayi et al, 2011;Odeyemi et al, 2014). The Malagasy species studied also showed in vitro antimicrobial properties (Randriamampianina et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the extracts of Albizia masikororum R.Vig., a Fabaceae from Madagascar

Razafindrakoto¹,

Randriamampianina²,

Vahinalahaja³

et al. 2018

Afr. J. Microbiol. Res.

View full text Add to dashboard Cite

This study is aimed at the assessment of antimicrobial potential of Albizia masikororum, a Malagasy Fabaceae. Hexanic and methanolic extracts from fruit pods, stem bark, leaves and seeds were tested by disc diffusion and microdilution methods on 10 pathogenic microorganisms including four Gram positive bacteria, five Gram negative bacteria and one yeast. Only the leaf and seed methanolic extracts, LME and SME respectively, were active on some bacteria. LME and SME had a broad-spectrum activity, with SME more effective. The minimum inhibitory concentration (MIC) values of both extracts were <1000 µg/ml of which 30% <100 µg/ml, 20% between 100 and 500 µg/ml and 50% between 500 and 1000 µg/ml. SME MICs ranked from 6.10 µg/ml (Streptococcus pneumoniae) to 781.25 µg/ml (Yersinia enterocolitica) and those of LME from 97.65 µg/ml (Streptococcus pneumoniae) to 781.25 µg/ml (Bacillus cereus, Streptococcus pneumoniae and Yersinia enterocolitica). LME was bactericidal on all sensitive bacteria whereas SME was bactericidal on some and bacteriostatic on others. Both extracts contained different chemical groups known for their antimicrobial properties, saponins in SME and phenolic compounds in LME.

show abstract

Studies on Anti Typhoid Properties of Aqueous Methanol Leaves Extract of Albizia ferruginea (Musase)

Cited by 5 publications

References 2 publications

Saponins from Genus Albizia: Phytochemical and Biological Review

Saponins from Genus Albizia: Phytochemical and Biological Review

Phytochemical screening, antiproliferative evaluation, and molecular docking studies of Acacia nilotica fruit from Nigeria

Antimicrobial activity of the extracts of Albizia masikororum R.Vig., a Fabaceae from Madagascar

Contact Info

Product

Resources

About