Studies on antioxidant and α-glucosidase inhibitory constituents of Chinese toon bud (Toona sinensis)

Xu, Rong; Bu, Yun-Ge; Zhao, Meng-Ling; Tao, Rong; Luo, Jun; Li, Yang

doi:10.1016/j.jff.2020.104108

Cited by 21 publications

(8 citation statements)

References 20 publications

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“…All these results suggested that 1-galloyl-glucose, gallic acid, methyl gallate, 1,6-digalloyl-β- d -glucose, and 1,3,6-trigalloylglucose are potential α-glucosidase inhibitors. Previously, N. Xue et al 43 and R. Xu et al 44 reported that gallic acid and methyl gallate showed α-glucosidase inhibitory activities with IC 50 values of 2.79 mmol L −1 and 0.23 mg mL −1 , respectively. Moreover, the α-glucosidase inhibitory effect of 1,6-digalloyl-β- d -glucose was reported and its IC 50 was 0.16 mg mL −1 .…”

Section: Resultsmentioning

confidence: 99%

In situnet fishing of α-glucosidase inhibitors from evening primrose (Oenothera biennis) defatted seeds by combination of LC-MS/MS, molecular networking, affinity-based ultrafiltration, and molecular docking

2022

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Section: Resultsmentioning

confidence: 99%

In situnet fishing of α-glucosidase inhibitors from evening primrose (Oenothera biennis) defatted seeds by combination of LC-MS/MS, molecular networking, affinity-based ultrafiltration, and molecular docking

2022

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“…The starch (polysaccharide) in food is digested by saliva and pancreatic amylase into oligosaccharides that enter the small intestine and are broken down by α-glucosidase located on the brush border of the jejunum epithelial cells [ 48 ]. The action of α-glucosidase inhibitors results in a reduction of the sugar absorption area and delay in the absorption time, which is beneficial for decreasing post-prandial hyperglycemia, and thus, is effective against diabetes [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Protection against Oxidative Stress and Metabolic Alterations by Synthetic Peptides Derived from Erythrina edulis Seed Protein

et al. 2022

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The ability of multifunctional food-derived peptides to act on different body targets make them promising alternatives in the prevention/management of chronic disorders. The potential of Erythrina edulis (pajuro) protein as a source of multifunctional peptides was proven. Fourteen selected synthetic peptides identified in an alcalase hydrolyzate from pajuro protein showed in vitro antioxidant, anti-hypertensive, anti-diabetic, and/or anti-obesity effects. The radical scavenging properties of the peptides could be responsible for the potent protective effects observed against the oxidative damage caused by FeSO4 in neuroblastoma cells. Moreover, their affinity towards the binding cavity of angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) were predicted by molecular modeling. The results demonstrated that some peptides such as YPSY exhibited promising binding at both enzymes, supporting the role of pajuro protein as a novel ingredient of functional foods or nutraceuticals for prevention/management of oxidative stress, hypertension, and metabolic-alteration-associated chronic diseases.

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“…27,29 Toona sinensis shoots are an ideal dietary vegetable, with abundant medicinal components. 30,31 Recently, Ismayati et al 32 progressive approach, we found that polyphenols, glycosides, and terpenoids were the major antimicrobial compounds. Moreover, many new compounds need to be excavated with high bioactivities.…”

Section: Introductionmentioning

confidence: 93%

“…The main components of Koelreuteria paniculata seeds are terpenoids and flavonoids, with anti‐Alzheimer's disease activity 27,29 . Toona sinensis shoots are an ideal dietary vegetable, with abundant medicinal components 30,31 . Recently, Ismayati et al 32 .…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and antibacterial activity of 12 medicinal plant ethyl acetate extracts using LC–MS feature‐based molecular networking

Yang

Chen

et al. 2022

Phytochemical Analysis

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Introduction: Widespread use of antibiotics has led to an increase in bacterial multiple drug resistance, thereby searching for natural antimicrobial agents from plants becomes an effective and alternative approach. In the present study, we selected six foodborne bacteria to evaluate the antibacterial activities of 12 medicinal plants ethyl acetate (EA) extracts. Objective: This study aims to search for natural antibiotic substitutes from plant extracts. The antibacterial components were further discussed through chemometric and mass spectroscopic analyses. Methodology: Agar well diffusion and the microdilution methods were used to test the antibacterial activity. Total phenolic content (TPC) and total flavonoid content (TFC) were used to judge the active phytochemicals. To further characterise the potential antibacterial components, an ultra-performance liquid chromatographyquadrupole-time of flight-mass spectrometry (UPLC-Q-TOF-MS) coupled with Pearson correlation and feature-based molecular network (FBMN) were proposed. Results: Most of the plant extracts possessed antibacterial activity against Bacillus subtilis and Salmonella typhi. Toona sinensis shoots and Firmiana simplex barks showed high inhibitory activities against Staphylococcus aureus, Shigella dysenteriae, andEscherichia coli strains with minimum inhibitory concentrations (MICs) of 1.56, 0.78, and 0.39 mg/mL, respectively. Salmonella typhi was highly sensitive to Firmiana simplex barks with an inhibitory diameter up to 21.67 ± 0.95 mm, and MIC at 0.78 mg/ mL. Moreover, Toona sinensis shoots and Firmiana simplex barks had the highest TPCs. Conclusion:Our results indicated that Toona sinensis shoots, Koelreuteria paniculate seeds, and Firmiana simplex barks could be supplied as potential sources of antimicrobial agents. Furthermore, 36 potential bioactive compounds were identified mainly as polyphenols, glycosides, and terpenoids.

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Studies on antioxidant and α-glucosidase inhibitory constituents of Chinese toon bud (Toona sinensis)

Cited by 21 publications

References 20 publications

In situnet fishing of α-glucosidase inhibitors from evening primrose (Oenothera biennis) defatted seeds by combination of LC-MS/MS, molecular networking, affinity-based ultrafiltration, and molecular docking

In situnet fishing of α-glucosidase inhibitors from evening primrose (Oenothera biennis) defatted seeds by combination of LC-MS/MS, molecular networking, affinity-based ultrafiltration, and molecular docking

Protection against Oxidative Stress and Metabolic Alterations by Synthetic Peptides Derived from Erythrina edulis Seed Protein

Chemical composition and antibacterial activity of 12 medicinal plant ethyl acetate extracts using LC–MS feature‐based molecular networking

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