Studies on biologically active heterocycles. Part I. Synthesis and antifungal activity of some new aroyl hydrazones and 2,5‐disubstituted‐1,3,4‐oxadiazoles

Abstract

A series of new 1‐(2,4‐dichlorobenzoyl) hydrazones and 2‐aryl/aralkyl‐5‐(2,4‐dichlorophenyl)‐1,3,4‐oxadiazoles have been synthesized from 2,4‐dichlorobenzoylhydrazine and different aldehydes. Subsequent ring closure of the substituted aroyl hydrazones yielded the 1,3,4‐oxadiazoles. All the compounds were characterized by their sharp melting point, microanalysis, ir, 1H nmr and mass spectra and screened for their fungitoxic properties against Alternaria tenuis and Curvularia verruciformis. A few of the compounds showed good activity.

Synthesis and Antimicrobial Activity of Some Derivatives on the Basis (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic Acid Hydrazide

“…On the other hand, a large number of hydrazides have been reported to be of biological interest [6,7], while oxadiazole derivatives and thiosemicarbazides have been reported to possess antibacterial [8,9], antifungal [10,11] and other biological activities. Furthermore, a number of substituted thiazolines and thiazolidinones were found to exhibit appreciable antimicrobial and antifungal activities [12][13][14][15][16]. It was therefore thought worthwhile to incorporate the hydrazide, thiosemicarbazide and oxadiazole moieties into the coumarin nucleus.…”

Design and syntheses of some new 5-[benzenesulphonamido]-1,3,4- thiadiazol-2-sulphonamide as potent antiepileptic agent

“…The 1,3,4-thiadiazole and its derivatives possess wide variety of activities. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Furthermore, 1,3,4-thiadiazole nucleus itself exhibit anticonvulsant activity. [23] This increases our interest to design compounds from QSAR study and synthesize the compounds accordingly, having better therapeutic index for epilepsy treatment and very low diuretic activity.…”

Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives

“…Disubstituted-1,3,4-oxadiazoles have been found to exhibit diverse biological activities such as antibacterial [20], antifungal [21], antitubercular [22], insecticidal [23], herbicidal [24], analgesic [25], anti-inflammatory [26], anticonvulsant [27] and anticancer [28].…”