Studies on Coordination Chemistry and Antibacterial Activity of Bidentate NS Schiff Base Derived From SBDTC and 4-Benzyloxybenzaldehyde

Abstract

The condensation of 4-benzyloxybenzaldehyde with S-benzyl dithiocarbazate (SBDTC) in absolute ethanol afforded the Schiff base, S-benzyl-β-N-(4-benzyloxyphenyl)methylene-dithiocarbazate (1). The ligand on further reaction with metal ions in absolute ethanol [for Ni(II), Cu(II), Zn(II)] and in methanol [Pd(II)] resulted in the formation of the corresponding four coordinate complexes. The ligand and its complexes were characterized by physico-chemical techniques, viz., molar conductance, magnetic susceptibility measurement, IR, NMR and solution UV/Vis spectroscopic techniques. The complexes demonstrated stronger antibacterial activity than the free ligand indicating that coordination with these metal ions has enhanced biological potential of the ligand. All the compounds exhibited more or less moderate activity against the test organisms.

Computational and experimental insight into antituberculosis agent, (E)-benzyl-2-(4-hydroxy-2-methoxybenzylidene) hydrazinecarbodithioate: ADME analysis

“…The FTIR spectra of compound 1 is depicted in Figure S1. The characteristic band was found at 3138 cm −1 (Figure S1, a) due to thione group of the studied compound [ 12 , 16 ] while the computed value was found to be 3460 cm −1 (Figure S1, b). A band at 1618 cm −1 in the studied compound is due to aromatic C=C bond [ 17 ], theoretically this band was observed at 1625 cm −1 .…”

“…Another characteristic band was observed at 1575 cm −1 in the experimental spectrum due to azomethine group [ 1 , 13 , 16 , 18 , 19 , 20 , 21 , 22 ], theoretically it was found at 1672 cm −1 . The symmetric stretching band of v (C=S) was found to be 1111 cm −1 [ 12 , 16 ] in the experimental spectrum while it was found at 1155 cm −1 in the computed spectrum. The computed vibrational frequencies are higher than their experimental results, because the computed values are obtained in gas phase while experimental values are obtained in solid phase.…”

“…An imine group (–RC = N–) containing Schiff bases are also used as dyes, intermediate reactants in the synthesis of organic compounds, catalysts, stabilizing agent in polymeric products, chelating agents in analytical separation methods and inhibitor of corrosion [ 10 , 11 ]. Moreover, Schiff bases possess noteworthy applications in multifaceted areas such in the solar cell, optical ingredients [ 6 , 7 , 9 , 12 ] and medication area such as antiviral, antifungal, antibacterial, insecticidal, anti-HIV, anticancer, antiprotozoal, antimalarial, anti-inflammatory, antidiabetic and antitumor [ 2 , 3 , 5 , 7 , 10 , 11 , 12 , 13 , 14 , 15 ]. From the point of view, we report herein the synthesis, characterization as well as investigation of in silico quantum calculations of the entitled SBDTC Schiff base in particulars.…”

Synthesis and Characterization of Some Mannich Base Analogues of Ciprofloxacin: Antibacterial, Antifungal, and Cytotoxic Activities

“…The antimicrobial activity of the derivatives was determined by the disc diffusion method [35][36][37][38] against Gram-positive, Gram-negative bacteria, and fungal strains. The organisms were accumulated as pure cultures.…”

Computational and Experimental Insight Into Antituberculosis Agent, (E)-Benzyl-2-(4- Hydroxy-2-Methoxybenzylidene) Hydrazinecarbodithioate: ADME Analysis

“…An imine group (-RC ¼ N-) containing Schiff bases are also used as dyes, intermediate reactants in the synthesis of organic compounds, catalysts, stabilizing agent in polymeric products, chelating agents in analytical separation methods and inhibitor of corrosion [10,11]. Moreover, Schiff bases possess noteworthy applications in multifaceted areas such in the solar cell, optical ingredients [6,7,9,12] and medication area such as antiviral, antifungal, antibacterial, insecticidal, anti-HIV, anticancer, antiprotozoal, antimalarial, anti-inflammatory, antidiabetic and antitumor [2,3,5,7,10,11,12,13,14,15]. From the point of view, we report herein the synthesis, characterization as well as investigation of in silico quantum calculations of the entitled SBDTC Schiff base in particulars.…”