Studies on DNA cleavage and antimicrobial screening of transition metal complexes of 4-aminoantipyrine derivatives of N2O2 type

Abstract

A new series of transition metal complexes of Cu(II), Ni(II), Zn(II) and VO(IV), were synthesized from the Schiff base (L) derived from 4-aminoantipyrine, 3-hydroxy-4-nitrobenzaldehyde and acetylacetone. The structural features were arrived from their elemental analyses, magnetic susceptibility, molar conductance, Mass, IR, UV-Vis., 1 H NMR and ESR spectral studies. The data show that the complexes have composition of [ML]X type. The UV-Vis., magnetic susceptibility and ESR spectral data of the complexes suggest a square-planar geometry around the central metal ion except for VO(IV) complex which has squarepyramidal geometry. The redox behavior of copper and vanadyl complexes were studied by cyclic voltammetry. The antimicrobial screening tests were also recorded and gave good results in the presence of metal ion in the ligand system. The nuclease activity of the above metal complexes shows that the copper and nickel complexes cleave DNA through redox chemistry, whereas other complexes are not effective.

Design, synthesis andin vitrobactericidal/fungicidal screening of some vanadyl(IV)complexes with mono- and di-substituted ONS donor triazoles

“…ligand charge transfer (MLCT). All these findings provided a strong evidence for the complexes to have a square-pyramidal geometry 38 .…”

In Vitro Biological Screening for Antimicrobial, DNA Cleavage Anti-Diabetic, Antioxidant, Anti-Inflammatory and Antihaemolytic of Some Metallocephalosporins

“…The DNA cleavage experiment was conducted using charge transfer DNA by gel electrophoresis with the corresponding metal complex in presence of H 2 O 2 as an oxidant [33][34]. One mg of DNA (0.1µg) was dissolved in 10ml buffer (50mM Tris-HCl-18 mM NaCl buffer pH=7.2), then 20µl was mixed with 2µl of compound and 10µl of H 2 O 2 (4%)and let to stand for 2.30 h in room temperature, after that the samples were electrophoreesed for 1h at 80 V [35][36][37][38].…”

Synthesis and Anticancer Activities of 4-[(Halophenyl)diazenyl]phenol and 4-[(Halophenyl)diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines

“…Azo molecules are known to be involved in the inhibition of DNA, RNA, carcinogenesis, and protein synthesis [19]. The presence of -N=N-in the molecular structure of azo is responsible for the interaction with the active site of protein [20]. The presence of halogen substituents in azo molecule also played an important role in the inhibition of receptor enzyme [21].…”