Studies on effect of CuO addition on mechanical properties and in vitro cytocompatibility in 1393 bioactive glass scaffold

Ali, Akher; Ershad,; Vyas, Vikash Kumar; Hira, Sumit Kumar; Manna, Partha Pratim; Singh, B. N.; Yadav, Shushma; Srivastava, Pradeep; Singh, Shailendra; Pyare, Ram

doi:10.1016/j.msec.2018.08.003

Cited by 48 publications

(16 citation statements)

References 63 publications

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“…49 Additionally, the effects of copper and/or zinc doped borate BGs have been evaluated in in vitro studies using fibroblasts, osteoblasts and endothelial cells considering similar BG compositions to those used in the present study. 40,45,46,48,[50][51][52][53][54][55] Although these published results are promising, they also showed that borate BGs, especially when doped with copper, could induce cytotoxic effects, particularly at high doses. 48,50 BGs have been extensively evaluated both in vitro and in vivo in their ability to improve bone and soft tissue regeneration, and so far several FDA approved BG compositions are commercially available in different forms (e.g.…”

Section: Biomaterials Science Papermentioning

confidence: 98%

Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependentin vitromodulation of murine dendritic cells

et al. 2020

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Section: Biomaterials Science Papermentioning

confidence: 98%

Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependentin vitromodulation of murine dendritic cells

et al. 2020

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“…In summary, the Cu-PEN composite prepared in this way could potentially be used in biomedical applications. The oxidation of CuNWs seems to be problematic for this field of study; nonetheless, Cu oxides are also referred to as an antibacterial agent [ 51 , 52 ] or even an improvement in biocompatibility [ 53 , 54 ]. For this reason, in our further experiments we intend to focus on the biological responses of such engineered surfaces.…”

Section: Resultsmentioning

confidence: 99%

Engineered Cu-PEN Composites at the Nanoscale: Preparation and Characterisation

et al. 2022

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As polymeric materials are already used in many industries, the range of their applications is constantly expanding. Therefore, their preparation procedures and the resulting properties require considerable attention. In this work, we designed the surface of polyethylene naphthalate (PEN) introducing copper nanowires. The surface of PEN was transformed into coherent ripple patterns by treatment with a KrF excimer laser. Then, Cu deposition onto nanostructured surfaces by a vacuum evaporation technique was accomplished, giving rise to nanowires. The morphology of the prepared structures was investigated by atomic force microscopy and scanning electron microscopy. Energy dispersive spectroscopy and X-ray photoelectron spectroscopy revealed the distribution of Cu in the nanowires and their gradual oxidation. The optical properties of the Cu nanowires were measured by UV-Vis spectroscopy. The sessile drop method revealed the hydrophobic character of the Cu/PEN surface, which is important for further studies of biological responses. Our study suggests that a combination of laser surface texturing and vacuum evaporation can be an effective and simple method for the preparation of a Cu/polymer nanocomposite with potential exploitation in bioapplications; however, it should be borne in mind that significant post-deposition oxidation of the Cu nanowire occurs, which may open up new strategies for further biological applications.

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“…Bioglasses were amorphous powder as received, with a mean particle size of d [50] = 4.5 µm and d [50] = 6.1 µm for BG 45S5 and BG 1393, respectively [55]. The chemical composition of BG 45S5 is 45 wt.% SiO 2 , 24.5 wt.% CaO, 24.5 wt.% Na 2 O and 6 wt.% P 2 O 5 [35], while for BG 1393 it is 53 wt.% SiO 2 , 20 wt.% CaO, 6 wt.% Na 2 O, 4 wt.% P 2 O 5 , 12 wt.% K 2 O and 5 wt.% MgO [56].…”

Section: Bioactive Bilayer Coatings: Deposition and Characterizationmentioning

confidence: 99%

Bioactive Bilayer Glass Coating on Porous Titanium Substrates with Enhanced Biofunctional and Tribomechanical Behavior

et al. 2022

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The use of porous titanium samples fabricated by space-holder powder metallurgy with bioactive coatings has already been reported to prevent resorption of the bone surrounding the implant and improve osseointegration, respectively. However, the presence of pores as well as the poor adherence and the brittle behavior inherent to glassy coatings affect the service behavior of implants fabricated from these samples. Therefore, they need to be optimized. In this work, 50 vol.% of porosity titanium substrates were manufactured with different pore range size (100–200 and 355–500 µm) spacer particles and coated with a bilayer of bioactive glasses (45S5/1393). The effect of the pores on the tribomechanical properties and infiltration of the bioactive glass 1393 along with the bioactivity of the bioactive glass 45S5 were evaluated by instrumented micro-indentation and scratch tests and the formation of hydroxyapatite in simulated body fluid. The results obtained were very promising as potential implants for the replacement of small tumors in cortical bone tissues, mainly due to the smaller pores that present an improved biomechanical and biofunctional balance.

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Studies on effect of CuO addition on mechanical properties and in vitro cytocompatibility in 1393 bioactive glass scaffold

Cited by 48 publications

References 63 publications

Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependentin vitromodulation of murine dendritic cells

Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependentin vitromodulation of murine dendritic cells

Engineered Cu-PEN Composites at the Nanoscale: Preparation and Characterisation

Bioactive Bilayer Glass Coating on Porous Titanium Substrates with Enhanced Biofunctional and Tribomechanical Behavior

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