Studies on Enzyme Elimination

U, Bär; Friedel, R. A.; Heine, Henry S.; Mayer, D. T.; Ohlendorf, S.; Schmidt, F. W.; Trautschold, I.

doi:10.1159/000459473

Cited by 14 publications

(2 citation statements)

References 17 publications

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“…There are five different LDH isoenzymes, which are tetramers composed of heart or muscle subunits. 2 The half-life of LDH in dogs is less than 6 h. 44 LDH is widely distributed in tissues, with the highest activity found in the liver, heart and skeletal muscles and kidneys. 22 Red blood cells also have a substantial LDH activity.…”

Section: Biological Variationmentioning

confidence: 99%

Clinical enzymology of the dog and cat

Oikonomidis,

Milne

2023

Aust Veterinary J

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Clinical enzymology studies the enzyme activity in serum or other body fluids for the diagnosis, prognosis or monitoring of a variety of diseases. Clinical enzymology has greatly benefited from advances in technology and is now an integral part of laboratory analysis. However, to maximise the clinical benefits of serum enzyme measurement, clinicians and clinical pathologists must have a good understanding of the pathophysiology behind serum enzyme alterations. They must also be aware of the preanalytical and analytical factors that can affect the accuracy of serum enzyme activity measurement. This review article first covers the basic concepts of clinical enzymology and the general mechanisms related to serum enzyme alterations. Then, the review discusses the potential effects of various preanalytical and analytical factors on enzyme activity measurement. Lastly, it explores the pathophysiology and clinical use of various serum enzymes in canine and feline medicine. The present review article aims to be a comprehensive one‐stop source for clinical pathologists and small animal practitioners.

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Section: Biological Variationmentioning

confidence: 99%

Clinical enzymology of the dog and cat

Oikonomidis,

Milne

2023

Aust Veterinary J

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“…Direct contributions of enzymes from the intracellular to the intravascular space (K 8), äs well äs exchanges äcross capillary membranes from the interstitial to the intravascular space (K 2), are of secondary importance. In addition, the elimination of enzymes from the interstitial space (K 5) is negligible (3,4). Rate constants of significant importance are represented by solid lines, rate constants of minor impör-tance by dashed lines.…”

Section: Introductionmentioning

confidence: 99%

Kinetic of Adjustment of Enzyme Catalytic Concentrations in the Extracellular Space of the Man, the Dog and the Rat. Approach to a Quantitative Diagnostic Enzymology, V. Communication

Lindena¹,

Diederichs²,

Wittenberg³

et al. 1986

Clinical Chemistry and Laboratory Medicine

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Summary:The high degree of constancy of enzyme catalytic activity in the plasma of a given individual is regulated by a coihplex System of flux equilibria consisting of eight basic processes. Some of these processes are of primarily theoretic importance. Enzymes from all tissues of the body, including the liver, are released via a continuous physiological process into the interstitial space and get into the intravascular space by way of lymphatic transport. The release of enzymes from tissues directly into the intravascular space is of secondary importance äs is the exchange of enzyme molecules across capillary membranes from the intravascular to the interstitial space and vice versa. In contrast, enzymes from circulating blood cells are transported directly into the intravascular space. Enzymes are removed from the intravascular space at rates which vary greatly between both enzymes and species. In a review of the literature, half-lives of diagnostically important enzymes in plasma of man, dogs and rats were given and the striking differences in the results for a given enzyme are discussed from a methodological point of view. In a mathematical analysis, data for lymphatic transport of enzymes from dogs and rats (Lindena et al. (1986) this J. 24, 19 -33) and of enzyme efflux from in vivo ageing erythrocytes (Lindena et al. (1986) this J. 24, 49 -59) into the plasma are related to the elimination rate constaiits of enzymes from the plasma. The contribution of lymphatically transported enzymes to the basal catalytic activity in plasma this J. 24, 11 -18) amounts to 55-80% for lactate dehydrogenase and rnalate dehydrogenase, 80 -90% for adenylate kiriase and phosphohexose isomerase, 90-95% for aspartate aminotransferase and aldolase and 99% for creatine kinase. A model of Ca 2+ rmediated vesicular transport of enzymes out of ageing erythrocytes is proposed. The importance of lymphatically transported enzymes to total plasma catalytic activity in dogs and rats argues for a similar contribution of lymph transport in man. Die Kinetik der Einstellung der kaialytischen Konzentration von Enzymen im Extrazellularraum bei

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Enzyme therapy in cyanide poisoning: Effect of rhodanese and sulfur compounds

Frankenberg

1980

Arch. Toxicol.

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Studies on Enzyme Elimination

Cited by 14 publications

References 17 publications

Clinical enzymology of the dog and cat

Clinical enzymology of the dog and cat

Kinetic of Adjustment of Enzyme Catalytic Concentrations in the Extracellular Space of the Man, the Dog and the Rat. Approach to a Quantitative Diagnostic Enzymology, V. Communication

Enzyme therapy in cyanide poisoning: Effect of rhodanese and sulfur compounds

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