Studies on Ferrocene and its Derivatives, VI. Cyclocondensation Reactions of Some Ferrocenyl Anils

Hassan, Kh. M.

doi:10.1515/znb-1978-1229

Cited by 13 publications

(1 citation statement)

References 8 publications

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“…[13][14][15][16][17] β-Lactams containing a ferrocene moiety [7,[18][19][20][21] at C-4 are important, because they are ideal candidates for drug design due to their low toxicity [22] and due to the ability of ferrocene to modify the β-lactam molecule in the third dimension by bringing the bulky metal complex in close proximity to the β-lactam ring without disturbing the molecule profile, which is necessary for antibiotic activity. [23] Besides their potential as antibacterial agents and potent enzyme inhibitors, nowadays a very attractive aspect of ferrocenyl-substituted compounds is their potential role as electrochemical markers in biological processes.…”

Section: Introductionmentioning

confidence: 99%

Conformational Analysis of β‐Lactam‐Containing Ferrocene Peptides

et al. 2009

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The homochiral 3-amino-1-(4-methoxyphenyl)-4-phenyl-β-lactam (ϵ Alm) was conjugated with Boc-Ala to give AlaAlm (9) after Boc deprotection (Boc = tert-butoxycarbonyl, Ala = alanine). Coupling of Fc-COOH (1) and Boc-Fca (10) with "dipeptide" 9 resulted in the formation of Fc-CO-AlaAlm (12) and the trisamide Boc-Fca-Ala-Alm (13), respectively (Fc = ferrocenyl, Fca = 1Ј-aminoferrocene-1-carboxylic acid). The reactions were accomplished by the HOBt/EDC procedure, and the products were obtained in good yields [HOBt = 1-hydroxybenzotriazole, EDC = N-(3-dimethylaminopropyl)-NЈ-ethylcarbodiimide hydrochloride]. Symmetrically 1,1Ј-disubstituted "tetrapeptide" Fn(CO-Ala-Alm) 2 (14)

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Section: Introductionmentioning

confidence: 99%

Conformational Analysis of β‐Lactam‐Containing Ferrocene Peptides

et al. 2009

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Bio‐Organometallic Derivatives of Antibacterial Drugs

Sierra

Casarrubios

Torre

2019

Chemistry A European J

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Overuse and misuse of antibacterial drugs has resulted in bacteria resistance and in an increase in mortality rates due to bacterial infections. Therefore, there is an imperative necessity of new antibacterial drugs. Bio-organometallic derivatives of antibacterial agents offer an opportunity to discover new active antibacterial drugs. These compounds are well-characterized products and, in several examples, their antibacterial activities have been studied. Both inhibition of the antibacterial activity and strong increase in the antibiotic activity of the parent drug have been found. The synthesis of the main classes of bio-organometallic derivatives of these drugs, as well as examples of the use of structure-activity relation&&Ok?&& (SAR) studies to increase the activity and to understand the mode of action of bio-organometallic antimicrobial peptides (BOAMPs) and platensimicyn bio-organometallic mimics is presented in this article.

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