Studies on Ferrocene and Its Derivatives. I. Reactions of Formylferrocene with α-Amino Acids

Abstract

The condensation reactions of formyl-ferrocene (I) with various α-amino acids and their esters were studied. The products are new Schiff bases (II) which may be of medicinal value.

Synthesis, characterization, X-ray crystal structure, luminescence, electrochemical and solvatochromism studies of new dimer of nickel and palladium complexes containing ferrocenyl imine ligand

“…Studying of Schiff bases derived from ferrocene carboxyaldehyde and their metal complexes is a quite attractive subject. Ferrocene-containing metal chelate complexes can be regarded as multi-nuclear molecules possessing both the features of organometallics and coordination chemistry [12]. Many studies on this class of ferrocene containing molecules have been reported recently.…”

Ferrocene substitution in amino acids strengthens the axial binding in Cu(ii) complexes and separates the hydrophobic and hydrophilic region in the crystals

“…7,8 Synthesis of ferrocenylmethyl derivatives has been reported before starting with the ester of histidine 7b or the solid state synthesis of the Schiff base form. 9 Interactions of non-redox active metal ions with ferrocene bound to glycine, aspartic and glutamic acid through amide linkages have been monitored using electrochemical studies. 10 However, redox active metal complexes with Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039, India.…”

Metal Complexes of Biologically Important Ligands, CLXXVI.[1] Formation of Peptides within the Coordination Sphere of Metal Ions and of Classical and Organometallic Complexes and Some Aspects of Prebiotic Chemistry

“…The N ‐ferrocenylmethyl amino acids (Fem‐amino acids205–212) are accessible from ferrocenealdehyde with α‐amino acids or esters and hydrogenation of the formed Schiff bases208 with Pd/H 2 205,206 or NaBH 4 207,209–212 (Equation (26)). Fem‐amino acid esters have been coupled with N‐protected amino acids205,206 (Equation (27)) and Fem‐amino acids with the free amino group of amino acids (or peptides)210 to give the corresponding ferrocene containing peptides (Equation (28)).…”