Studies on Glutaraldehyde Crosslinked Chitosan Hydrogel Properties for Drug Delivery Systems

Shafiee, Mojtaba; Danaei, M.

doi:10.1080/00914037.2013.769165

Cited by 172 publications

(98 citation statements)

References 11 publications

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“…23,25,26 Previous reports point out that the high intensity of the (111) plane is due to its lower surface free energy compared to the others. 18 An unidentified peak around 54.88, obtained by the crystallization of the reducing and stabilizing agent used in the synthesis, was also observed in the XRD pattern of AgNPs along with its characteristic peaks.…”

Section: Characterizationmentioning

confidence: 97%

“…25 CT is the second most abundant nontoxic cationic polysaccharide, composed of b-(1,4)22-amino-2-deoxy-D-glucose and is widely used in the biomedical field because of its excellent physiochemical properties and its biocompatibility and biodegradability in an aqueous environment. [26][27][28][29] Our research group has already reported the use of a thiolated chitosan/poly(lactic acid) blend incorporated in methionine-modified montmorillonite for the controlled release of amoxicillin (AMO) in the intestinal pH. 30 The hydrophilic nature and higher solubility of CT in an acidic medium prevents its ability to control the release of drug molecules.…”

Section: Introductionmentioning

confidence: 99%

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Functionalized polymeric silver nanoparticle hybrid network as a dual antimicrobe:Synthesis, characterization, and antibacterial application

Anirudhan

Binusreejayan

2016

J of Applied Polymer Sci

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The present work describes a novel method for the synthesis of silver polymer nanocomposite for the delivery of amoxicillin (AMO). Silver nanoparticles (AgNPs) were synthesized with chitosan and silver nitrate. The reaction parameters were optimized. Three-dimensional polymeric networks were synthesized by simple free-radical graft copolymerization. UV-visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, SEM, atomic force microscopy, dynamic light scattering, and zeta potential analysis were used for the complete characterization of the samples. Swelling studies and swelling factors were evaluated. In vitro release of AMO and AgNPs at physiological pHs was analyzed using the Peppas kinetic model to explain the drug delivery mechanism. Cytotoxicity, free-radical scavenging, and antibacterial activities were analyzed. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43479.

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Section: Characterizationmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Functionalized polymeric silver nanoparticle hybrid network as a dual antimicrobe:Synthesis, characterization, and antibacterial application

Anirudhan

Binusreejayan

2016

J of Applied Polymer Sci

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“…As modificações físico-químicas surgem como uma alternativa para minimizar estes problemas, e assim incrementando o desempenho da quitosana como material adsorvente (Rinauldo et al, 2006). De tal modo, o hidrogel de quitosana possibilita melhor estabilidade em soluções ácidas, capacidade de reuso, facilidade de separação, além de diminuir o custo do adsorvente, sendo que o glutaraldeído é um dos agentes reticulantes mais utilizados para modificação da quitosana (Mirzaei et al, 2013).…”

Section: Introductionunclassified

Cinética De Adsorção Dos Corantes Azul Brilhante E Vermelho N° 40 Por Hidrogéis De Quitosana Em Sistema Binário

Silva¹,

Rios²,

Martins³

et al. 2017

Blucher Chemical Engineering Proceedings

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RESUMO -Os hidrogéis de quitosana são estruturas tridimensionais poliméricas que podem apresentar em sua estrutura um agente reticulante. Com o intuito de melhorar a estabilidade em soluções ácidas e facilitar o reuso do adsorvente a modificação de hidrogeís se torna viável na remoção de corantes em efluentes. O objetivo deste trabalho foi obter hidrogéis a base de quitosana, realizar a modificação com carvão ativado e verificar seu comportamento cinético na adsorção de corantes em sistema binário. Os hidrogéis, com e sem adição de carvão ativado foram liofilizados e após, caracterizados quanto a seu grau de intumescimento e força de gel. O estudo cinético foi realizado utilizando os corantes alimentícios azul brilhante e vermelho n° 40, agitados a 100 rpm à temperatura ambiente. Os dados experimentais foram ajustados ao comportamento cinético através dos modelos pseudoprimeira ordem, pseudossegunda ordem e Avrami. As capacidades de adsorção foram de 204 mg g -1 e 175 mg g -1 para o hidrogel sem e com carvão, respectivamente. O modelo de Avrami foi o que melhor se ajustou aos dados (R 2 >0,95 e EMR>7%).

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“…Cross-linking process has extremely significance for technological applications. [25][26][27][28] This process provides good mechanical and physical properties. Also, the cross-linked PANI derivatives can be gelled in organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of poly(m-aminophenol)-succinat

Dinç

Yalçınkaya

Altuntaş

et al. 2014

Designed Monomers and Polymers

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Poly(m-aminophenol) (PMAP) and poly(m-aminophenol)-succinat compound (PMAP-Suc) containing ester bridge were synthesized in this study. PMAP were synthesized by chemical oxidative polymerization of m-aminophenol (MAP) in HCl medium with ammonium peroxydisulphate (APS) as an initiator at different temperatures. The optimum polymerization conditions (temperature: 25°C, reaction time: 4 h, normalized MAP/APS ratio, k: 0.625 and mol of MAP/mol of APS, r: 0.5) of PMAP were determined. PMAP was esterified in N-methyl pyrrolidone by using solution of succinic acid as cross-linking agent and concentrated sulphuric acid as catalyst under appropriate ambient conditions. The general scheme of esterification and cross-linking reaction for PMAP is proposed. These reactions were also evidenced by spectroscopic, thermal and surface morphology as well as structural characteristics relationship of macromolecules. The structures of PMAP and PMAP-Suc were characterized by solubility test, FTIR, 1 H NMR and 13 C NMR, UV-vis spectroscopy, thermal (TGA-DTA) and SEM analyses.

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Studies on Glutaraldehyde Crosslinked Chitosan Hydrogel Properties for Drug Delivery Systems

Cited by 172 publications

References 11 publications

Functionalized polymeric silver nanoparticle hybrid network as a dual antimicrobe:Synthesis, characterization, and antibacterial application

Functionalized polymeric silver nanoparticle hybrid network as a dual antimicrobe:Synthesis, characterization, and antibacterial application

Cinética De Adsorção Dos Corantes Azul Brilhante E Vermelho N° 40 Por Hidrogéis De Quitosana Em Sistema Binário

Synthesis and characterization of poly(m-aminophenol)-succinat

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