Studies on Human Foetal Haemoglobin. III. The Hereditary Haemoglobinopathies and Thalassaemias

Beaven, G. H.; Ellis, M.; White, John

doi:10.1111/j.1365-2141.1961.tb00327.x

Cited by 45 publications

(17 citation statements)

References 35 publications

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“…The mean percentage of Hb F for the entire group was 2.35±1.40 (1 SD). These findings are similar to those of Caucasians (14) and Negroes (3) with fi-thalassemia trait previously reported. Two family members with sickle f8-thalassemia were also included to make a total group of 26 heterozygotes.…”

Section: Resultssupporting

confidence: 81%

β-Thalassemia in the American Negro

Friedman¹,

Rw²,

Schwartz³

1973

J. Clin. Invest.

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A B S T R A C T In Italian patients with high hemoglobinA2 fl-thalassemia trait, the synthesis of P-chains of adult hemoglobin in the peripheral blood is approximately one-half that of a-chains. In this study the relative rates of f-and a-chain synthesis were determined in 26 Negro heterozygotes and five homozygotes for fi-thalassemia in six families. The 8/a ratio of globin synthesis was decreased in only 15 heterozygotes, whereas in the other 11, fl/a globin synthesis was in the normal range or was slightly increased. These unusual findings did not appear to be due to the presence of a-thalassemia or a hyperactive "normal" fl-allele. This study demonstrates that the f8/a ratio of globin synthesis in the peripheral blood is normal in some patients with

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Section: Resultssupporting

confidence: 81%

β-Thalassemia in the American Negro

Friedman¹,

Rw²,

Schwartz³

1973

J. Clin. Invest.

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“…The proposed technique which has been utilized in our labora tory for over a year, gives quantitative and analytical results very near to the data reported by many authors, who have used different procedures (1,2,3,4,5,11,12,16,17,20,21,22,23,26,27,29,30,31,32,33,38,39). This method completes the separative electro phoretic technique of haemoglobins on starch-gel : in fact, it makes possible to dose carefully each haemoglobin and protein fraction.…”

Section: Discussionsupporting

confidence: 60%

A Simple Method for the Quantitation of Haemoglobin Fractions Obtained by Starch-Gel Electrophoresis

Ricco¹,

Gallo²,

Fiorina³

et al. 1967

Acta Haematol

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“…The nature of Hb-F from subjects with /?-thalassemia places these individu- 1 Percentages of Hb-F in parentheses were determined by DEAE-Sephadex chromatography only [8,17]; such values usually agree with %Fji 0 values if the percent Hb-F is large. 4 n.d., not determined.…”

Section: Discussionmentioning

confidence: 99%

“…Although this residue may not be Hb-F alone [10,22], it is generally assumed to contain variable amounts of the same Hb-F that is present in cord blood [10,13,15,26]. However, appre-493 ciable amounts of Hb-F can be detected in the peripheral blood of individuals 6 months of age and older who have an acquired heniatologic disorder or a genetic abnormality, such as /J-thalassemia or a hemoglobinopathy [3,4,6,7,11,31].…”

Section: Introductionmentioning

confidence: 99%