Studies on immunity, by Robert Muir...in collaboration with Carl H. Browning, M. D., Alexander R. Ferguson, M. D. and William B. M. Martin.

Ion-exchange reactions between acid mucopolysaccharides and various cations

“…This indicates a probable difference in physical configuration in solution between the two types of molecule. This difference obviously arises from the difference in chemical structure between the two compounds, namely the presence of D-glucuronic acid in chondroitin sulphate A and of L-iduronic acid in chondroitin sulphate B, the remaining parts of the molecules being identical (Muir, 1961). Mathews (1960) has indicated that chondroitin sulphate B binds cations more strongly than does chondroitin sulphate A.…”

Structure of a styrylbenzoxazole derivative

“…Moreover, two platinum(II) complexes of the type [Pt(L)Br3]NEt4, L =2-(2-hydroxystyryl)-and 2-(2,5-dichloro-5-nitrostyryl)benzothiazole, respectively, show good cytotoxic activity against CHO-K cells in vitro (Muir, Cadiz & Baez, 1988). The X-ray crystal structures of several Pt n styrylbenzothiazole complexes have been determined (Muir, G6mez, Muir, Cox & Cadiz, 1987;G6mez, Muir, Muir & Cox, 1988;Muir, G6mez, Muir, Cadiz, Cox & Barnes, 1988;Muir, G6mez, Muir & Cadiz, 1990). The average C--S--C angle in the thiazole rings of those compounds was 90.2 (4) ° , which is considerably smaller than the C--O--C angle of 103.7 (3) ° in nsbo.…”

Studies on the Berkefeld-Filtration of Complement

“…AB dose = 0-0025 c.c., the total volume being 1-5 c.c. The saturation of the filter surface can also be effected by the previous filtration of a thermo-inactivated serum as has been done by Muir and Browning (1909). A similar experiment was made by Holderer (1912), who effected the filtration of diastase through a Chamberland candle after the previous filtration of an albumin solution.…”

“…Muir and Browning (1909) found that by filtration through a Berkefeld filter the complement of a guinea-pig serum is retained by the filter to a large extent-sometimes indeed completely,--but if more serum is filtered it passes through. Neufeld and Andrejew (1909) and Andrejew (1910) found that out of all immune bodies in serum, complement is the most completely retained by filtration through Kieselguhr.…”

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INTRODUCTORY.IN view of the divergent results obtained in recent work dealing with the effect of Berkefeld filtration on the haemolytic complement of serum, I think that the publication of the results which I have obtained during some investigations, which I have been carrying out on the inactivation of complement by shaking, may not be without value.Muir and Browning (1909) found that by filtration through a Berkefeld filter the complement of a guinea-pig serum is retained by the filter to a large extent-sometimes indeed completely,--but if more serum is filtered it passes through. Neufeld and Andrejew (1909) and Andrejew (1910) found that out of all immune bodies in serum, complement is the most completely retained by filtration through Kieselguhr.

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