Studies on Interionic Interactions of Anti-Tuberculosis Drugs Isoniazid with Mixed Solvents at Different Temperatures: Ultrasonic Studies

Abstract

Density, ρ, and ultrasonic velocity, u of an anti-tuberculosis drug, isoniazid, INH in the aqueous solutions of potassium citrate, K3Cit, and sodium citrate, Na3Cit were determined at T= (298.15 to 318.15) K and, p =0.1MPa atmospheric pressure. The thermo-acoustic properties like isothermal compressibility (βT), heat capacity ratio (g), molar compression (W), acoustic impedance (Z), molar sound velocity(R), relative association (RA), intermolecular free length (Lf), relaxation time, coefficient of thermal expansion(α), and non-linearity parameters have been evaluated from ultrasonic velocity, u, and density, ρ at the studied temperature T= (298.15 to 318.15) K. The results obtained by these processes have been used to analyze the presence of intermolecular interactions existing in the solutions system (INH+Water+K3Cit/Na3Cit). The concentration and temperature effect of the solutions on intermolecular forces were studied at the same pressure