Studies on pectin coating of liposomes for drug delivery

Nguyen, Sanko; Alund, Siv Jorunn; Hiorth, Marianne; Kjøniksen, Anna–Lena; Smistad, Gro

doi:10.1016/j.colsurfb.2011.07.058

Cited by 91 publications

(44 citation statements)

References 23 publications

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“…The liposomes were prepared according to the film method, as described by Nguyen et al [18]. DPPC and DPTAP (10 mol%), were dissolved in chloroform and the solvent was evaporated in a rotary evaporator.…”

Section: Preparation Of the Liposomesmentioning

confidence: 99%

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Characterization of temperature induced changes in liposomes coated with poly( N -isopropylacrylamide- co -methacrylic acid)

Klemetsrud

Hiorth

Smistad

et al. 2015

Journal of Colloid and Interface Science

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Section: Preparation Of the Liposomesmentioning

confidence: 99%

“…Additionally, charged liposomes can be coated with an oppositely charged polymer by electrostatic deposition. This technique is well suited for polymers such as chitosan [8,15,16], pectin [7,17,18] and eudragit [19,20].…”

Section: Introductionmentioning

confidence: 99%

Characterization of temperature induced changes in liposomes coated with poly( N -isopropylacrylamide- co -methacrylic acid)

Klemetsrud

Hiorth

Smistad

et al. 2015

Journal of Colloid and Interface Science

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“…The present investigation intended to use solid lipid to encapsulate the CMN solid dispersion into SLNs to increase the solubility, and the pectin coating can improve the stability of drug at different pH levels (Nguyen, Alund, Hiorth, Kjoniksen, & Smistad, 2011). This investigation could upgrade the anticancer activity, cellular uptake, and enhance the bioavailability of CMN via the oral route.…”

Section: Introductionmentioning

confidence: 99%

Skimmed milk powder and pectin decorated solid lipid nanoparticle containing soluble curcumin used for the treatment of colorectal cancer

Moideen

Kavitha

Kandhasamy

et al. 2019

J Food Process Engineering

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This research is aimed at the preparation of biopolymeric skimmed milk powder (SMP) and pectin coated dual layer solid lipid nanoparticles loaded with soluble curcumin (CMN) to enhance the cytotoxicity of the drug delivered to the colon for colorectal cancer (CRC). The curcumin (C‐) and curcumin solid dispersion (C‐SD) (soluble curcumin) loaded solid lipid nanoparticle (SLN) (C‐SD‐SLN) are prepared by hot homogenization method and characterized its physicochemical properties. The surface of the C‐SD‐SLNs was coated with natural biopolymers of pectin and skimmed milk powder (SMP), called cetyl palmitate (CP)‐SD‐SLN. The resultant nanoparticles showed significantly high drug loading, better stability, and slower release profile (92.1%) in various GI conditions up to 72 H. zebra fish toxicity studies of CP‐SD‐SLN confirm its in vivo safety, and the result from in vitro cytotoxicity showed that 50% inhibition (26 μM/ml) is achieved with an amount of CP‐SD‐SLN, which was considerably lesser than free CMN. The result from flow cytometry analysis confirmed the cell cycle arrest in the G2/M phase (49.11%), and western blot analysis was performed to understand its molecular level apoptosis in Caco‐2 cells. The profound efficiency of SMP and pectin coated CP‐SD‐SLN is a promising preparation that indicated its potential application for CRC treatment without toxicity. Practical application The pharma and biotech industry is seeking techniques to increase potential and reduce the toxicity of chemotherapeutic agents. The solid lipid nanoparticle (SLN) has fascinated significant attention in anticancer drug delivery generally because of the targeted delivery to the particular site and devoid of other tissues. The present investigation provides the efficiency of skimmed milk powder (SMP)‐coated lipid shell contains soluble curcumin to release the drug at colon and improve the metabolism and therefore increase the potential activity several fold than native curcumin. The results show that SMP and pectin coated SLN is a potential carrier for delivery to the colon and thus improve anticancer potential of human adenocarcinoma (Caco‐2) cells of curcumin. These results will contribute in designing SLN techniques for optimizing the wide‐ranging quality of natural curcumin.

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“…Many efforts have been undertaken to increase the stability and integrity of liposomes in the GIT either by coating the vesicles with polymers, such as chitosan, polyethylene glycol and pectin (Immordino et al, 2006;Nguyen et al, 2011;Parmentier et al, 2011;Kowapradit et al, 2012), or by inclusion of tetraether lipids or gangliosides within their structures (Torchilin, 2005). Recently, BS-liposomes have been investigated as stable carriers for delivering sensitive therapeutic agents and proteins by replacing a fraction of the CH in the lipid bilayers with bile salts (Guan et al, 2011;Niu et al, 2011Niu et al, , 2012Niu et al, , 2014.…”

Section: Bile Salts-containing Liposomes (Bs-liposomes)mentioning

confidence: 99%

Bile salts-containing vesicles: promising pharmaceutical carriers for oral delivery of poorly water-soluble drugs and peptide/protein-based therapeutics or vaccines

Aburahma¹

2014

Drug Delivery

103

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Most of the new drugs, biological therapeutics (proteins/peptides) and vaccines have poor performance after oral administration due to poor solubility or degradation in the gastrointestinal tract (GIT). Though, vesicular carriers exemplified by liposomes or niosomes can protect the entrapped agent to a certain extent from degradation. Nevertheless, the harsh GIT environment exemplified by low pH, presence of bile salts and enzymes limits their capabilities by destabilizing them. In response to that, more resistant bile salts-containing vesicles (BS-vesicles) were developed by inclusion of bile salts into lipid bilayers constructs. The effectiveness of orally administrated BS-vesicles in improving the performance of vesicles has been demonstrated in researches. Yet, these attempts did not gain considerable attention. This is the first review that provides a comprehensive overview of utilizing BS-vesicles as a promising pharmaceutical carrier with a special focus on their successful applications in oral delivery of therapeutic macromolecules and vaccines. Insights on the possible mechanisms by which BSvesicles improve the oral bioavailability of the encapsulated drug or immunological response of entrapped vaccine are explained. In addition, methods adopted to prepare and characterize BSvesicles are described. Finally, the gap in the scientific researches tackling BS-vesicles that needs to be addressed is highlighted.

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Studies on pectin coating of liposomes for drug delivery

Cited by 91 publications

References 23 publications

Characterization of temperature induced changes in liposomes coated with poly( N -isopropylacrylamide- co -methacrylic acid)

Characterization of temperature induced changes in liposomes coated with poly( N -isopropylacrylamide- co -methacrylic acid)

Skimmed milk powder and pectin decorated solid lipid nanoparticle containing soluble curcumin used for the treatment of colorectal cancer

Bile salts-containing vesicles: promising pharmaceutical carriers for oral delivery of poorly water-soluble drugs and peptide/protein-based therapeutics or vaccines

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