Studies on phytochemical and In-Vitro antioxidant potential of Justicia beddomei (Clarke) Bennett

Marathakam, Akash; Kannappan, N.; Jasemine, S.; Santhiagu, A.; Sreejith, M; Ajith, Mathew Puthenpurackal

doi:10.5530/ax.2012.4.5

Cited by 8 publications

(11 citation statements)

References 25 publications

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“…Justicia species are used in folk medicine for the treatment of numerous pathologies, such as depression, anemia, epilepsy, kidney infection, respiratory problems, gastrointestinal diseases, arthritis and fever [ 8 ]. Other biological activities have been determined from the plant extracts of Justicia , such as antioxidant [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ], antimutagenic [ 18 , 19 ], anticancer [ 22 , 23 , 24 , 25 ], anti-HIV [ 26 , 27 , 28 , 29 , 30 , 31 ], antimicrobial [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ], antidiabetic [ 43 , 44 , 45 ], among others. It is worth mentioning that there is currently relevant interest among research groups in evaluating a possible analgesic, anti-inflammatory and antiulcerogenic activity.…”

Section: Introductionmentioning

confidence: 99%

Overview of the Justicia Genus: Insights into Its Chemical Diversity and Biological Potential

et al. 2023

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The genus Justicia has more than 600 species distributed in both hemispheres, in the tropics and temperate regions, and it is used in the treatment of numerous pathologies. This study presents a review of the biological activities of plant extracts and isolated chemical constituents of Justicia (ACANTHACEAE), identified in the period from May 2011 to August 2022. We analyzed over 176 articles with various biological activities and chemical compound descriptions present in the 29 species of Justicia. These have a variety of applications, such as antioxidant and antimicrobial, with alkaloids and flavonoids (e.g., naringenin) the most frequently identified secondary metabolites. The most observed species were Justicia gendarussa Burm., Justicia procumbens L., Justicia adhatoda L., Justicia spicigera Schltdl, and Justicia pectoralis Jacq. The frontier molecular orbitals carried out using density functional theory (M062X and basis set 6-311++G(d,p) indicate reactive sites for naringenin compound and a chemical reaction on phytomedicine activity. The energy gap (206.99 kcal/mol) and dimer solid state packing point to chemical stability. Due to the wide variety of pharmacological uses of these species, this review points toward the development of new phytomedicines.

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Section: Introductionmentioning

confidence: 99%

Overview of the Justicia Genus: Insights into Its Chemical Diversity and Biological Potential

et al. 2023

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“…Therefore, increases the interest in isolation and characterization of plant-derived antioxidants. 4 Memecylon edule Roxb. (Melastamataceae family) is an evergreen tree found in Eastern and Western Ghats of India.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Compound Quercetin-3-O-α-L-rhamnoside(1→6)- β-D-glucose (Rutin) isolated from ethyl acetate leaf extracts of Memecylon edule Roxb (Melastamataceae)

2015

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Introduction:The present study was aimed to isolate antioxidant principle from leaf ethyl acetate extract of Memecylon edule for the first time. M. edule belongs to melastomataceae family; possess various biological properties and folklore uses. Methods: Isolation of antioxidant compound was carried out by DPPH radicals scavenging activity guided method and employing chromatography techniques (TLC and column chromatography). The structure of isolated bioactive compound (Rutin) was confirmed by using various spectral data like UV, FT-IR, LC-MS, CHNS analysis, 1 H-NMR, 13 C-NMR, DEPT-135, HMBC and HSQC. In vitro antioxidant activity of isolated compound was evaluated by using DPPH radical, nitric oxide radical, superoxide radical, hydroxyl radical scavenging assays and ferric reducing antioxidant power assay (FRAP) with reference to ascorbic acid and butylated hydroxyanisole (BHA). One way analysis of variance (ANOVA) and Tukey's multiple comparison tests were performed. Results: DPPH activity guided isolation resulted isolation of Rutin. Isolated rutin exhibited remarkable scavenging capacity on all tested radicals in a concentration dependent manner. The results also showed that Rutin harbor strong reductive capacity on hydroxyl radicals with lowest IC 50 value (17.06 µg/ml) and strong ferric ion (Fe

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“…Over production of oxidants in certain condition can cause imbalance leading to oxidative damage to large biomolecules such as lipids, DNA and proteins. Many synthetic drugs protect against oxidative damage but they have adverse side effects [21] . Data from both scientific reports and laboratory studies show that the plant contain a large variety of substance called "plant chemicals" or "phytochemicals" that possess antioxidant activity [22,23] .…”

Section: Antioxidant Assaymentioning

confidence: 99%

Phytochemical, Anti-oxidant and Anthelmintic activities of various leaf extracts of Flacourtia sepiaria Roxb

Sreejith

Kannappan

Santhiagu

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Studies on phytochemical and In-Vitro antioxidant potential of Justicia beddomei (Clarke) Bennett

Cited by 8 publications

References 25 publications

Overview of the Justicia Genus: Insights into Its Chemical Diversity and Biological Potential

Overview of the Justicia Genus: Insights into Its Chemical Diversity and Biological Potential

Antioxidant Compound Quercetin-3-O-α-L-rhamnoside(1→6)- β-D-glucose (Rutin) isolated from ethyl acetate leaf extracts of Memecylon edule Roxb (Melastamataceae)

Phytochemical, Anti-oxidant and Anthelmintic activities of various leaf extracts of Flacourtia sepiaria Roxb

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