Studies on skin aging. Preparation and properties of fucose-rich oligo- and polysaccharides. Effect on fibroblast proliferation and survival

Péterszegi, G.; Isnard, N.; Robert, A.M.; Robert, L.

doi:10.1016/s0753-3322(03)00031-3

Cited by 67 publications

(37 citation statements)

References 16 publications

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“…For the current investigation these plants have been chosen with a focus on their high polysaccharide contents. In the past years, polysaccharides were identified as compounds with multiple effects; amongst others were reduction of skin ageing (Peterszegi et al, 2003) and tissue regeneration (Biagini et al, 1991). Pivotal for the regeneration and remodeling of skin are the dermal fibroblasts of the connective tissue and the epidermal keratinocytes.…”

Section: Introductionmentioning

confidence: 99%

Time-dependent bioactivity of preparations from cactus pear (Opuntia ficus indica) and ice plant (Mesembryanthemum crystallinum) on human skin fibroblasts and keratinocytes

Deters

Meyer

Stintzing

2012

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Time-dependent bioactivity of preparations from cactus pear (Opuntia ficus indica) and ice plant (Mesembryanthemum crystallinum) on human skin fibroblasts and keratinocytes

Deters

Meyer

Stintzing

2012

Journal of Ethnopharmacology

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“…The experimental formulations were supplemented with 10% of polysaccharides of biotechnological origin (formulation A) or 3% Myrtus communis hydrolyzed extract (formulation B) or a combination of both (formulation C). The radiation-sterilized polysaccharides were produced by a non-pathogenic strain of Klebsiella pneumoniae and have an apparent average molecular weight of about 40 kDa (Péterszegi et al, 2003).…”

Section: Formulationsmentioning

confidence: 99%

Immediate and long-term effects of polysaccharides-based formulations on human skin

Camargo

Gaspar

Campos

2012

Braz. J. Pharm. Sci.

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A new trend in cosmetic formulations is the use of biotechnological raw materials as the polysaccharides from Klebsiella pneumoniae, which are supposed to enhance cell renewal, improve skin hydration and micro-relief. Botanical extracts of Myrtus communis leaves contain different sugars, which may provide the same benefits. Thus, the objective of this study was to evaluate through objective and subjective analysis the immediate and long-term effects of cosmetic formulations containing polysaccharides biotechnologically-originated and / or the ones contained in Myrtus communis extracts. Three polysaccharide-based and placebo formulations were applied on the forearm skin of 40 volunteers. Skin hydration, transepidermal water loss (TEWL), viscoelasticity and skin micro-relief measurements were made before and 2 hours after a single application and after 15 and 30 day-periods of daily applications. Answers to a questionnaire about perceptions of formulation cosmetic features constituted the subjective analysis. All polysaccharide-based formulations enhanced skin hydration. Formulations with isolated or combined active substances improved skin barrier function as compared to placebo, in the short and long term studies. Formulations containing Myrtus communis extracts had the highest acceptance. Results suggest that daily use of formulations containing these substances is important for protection of the skin barrier function. Uma nova tendência em formulações cosméticas é a utilização de matérias-primas biotecnológicas como os polissacarídeos de Klebsiella pneumoniae, que pode aumentar a renovação celular e melhor a hidratação e micro-relevo da pele. Por outro lado, o extrato vegetal de Myrtus communis contém diferentes polissacarídeos, que também podem proporcionar benefícios à pele. Assim, o objetivo do estudo foi a avaliação dos efeitos imediatos e em longo prazo, de formulações cosméticas contendo polissacarídeos obtidos por processo biotecnológico e/ou de extrato de M. communis por meio de análises objetivas e subjetivas. Três formulações contendo os polissacarídeos e um placebo foram aplicadas na pele dos antebraços de 40 voluntários. As medidas foram realizadas antes e após 2 horas da aplicação das formulações e após 15 e 30 dias de aplicações diárias em termos de hidratação da pele, perda transepidérmica de água (TEWL), viscoelasticidade e micro-relevo da pele. Para a análise subjetiva, os voluntários responderam um questionário a fim de obter-se informações sobre a percepção relativa à qualidade de cosméticos. Todas as formulações provocaram aumento da hidratação cutânea. As formulações que continham os polissacarídeos melhoraram a função barreira da pele, em curto e em longo prazo. A formulação contendo extrato de M. communis apresentou maior aceitação. Os resultados sugerem que o uso diário dos polissacarídeos avaliados é importante na proteção da função barreira da pele.Unitermos: Polissacarídeos/uso cosmético. Klebsiella pneumoniae/uso cosmético. Myrtus communis/ uso cosmético. Formulações cosméticas/aval...

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“…It is also considerable that the up-regulation of ROS generation and phagocytic uptake by KML may be connected to its binding to surface galactose-containing proteins (Wu et al, 1992;Lee et al, 2007). Some of these receptor proteins have been reported to be biochemically associated with receptor-mediated endocytosis as well as ROS generating enzyme systems such as NADPH oxidase (Currie et al, 2000;Peterszegi et al, 2003). ERK and p38 are also addressed to play a critical role in receptor-mediated cellular responses such as ROS generation (Parinandi et al, 2003).…”

Section: Time (Min)mentioning

confidence: 99%

Extracellular Signal-Regulated Kinase Is a Major Enzyme in Korean Mistletoe Lectin-Mediated Regulation of Macrophage Functions

Byeon¹,

Lee²,

Yu³

et al. 2009

Biomolecules and Therapeutics

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-Korean mistletoe lectin (KML) is the major component found in Viscum album var. (coloratum), displaying anti-cancer and immunostimulating activities. Even though it has been shown to boost host immune defense mechanisms, the regulatory roles of KML on the functional activation of macrophages have not been fully elucidated. In this study, regulatory mechanism of KML on macrophage-mediated immune responses was examined in terms of KML-mediated signaling event. KML clearly induced mRNA expression of tumor necrosis factor (TNF)-α, the generation of reactive oxygen species (ROS) and phagocytic uptake in RAW264.7 cells. All of these events were strongly suppressed by U0126, whereas TNF-α mRNA was not diminished by SB203580 and SP600125, indicating ERK as a central enzyme managing KML-induced up-regulation of macrophage functions. Indeed, KML strongly induced the phosphorylation of ERK in a time-dependent manner without altering its total level. Therefore, these data suggest that ERK may be a major signaling enzyme with regulatory property toward various KML-mediated macrophage responses.

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Studies on skin aging. Preparation and properties of fucose-rich oligo- and polysaccharides. Effect on fibroblast proliferation and survival

Cited by 67 publications

References 16 publications

Time-dependent bioactivity of preparations from cactus pear (Opuntia ficus indica) and ice plant (Mesembryanthemum crystallinum) on human skin fibroblasts and keratinocytes

Time-dependent bioactivity of preparations from cactus pear (Opuntia ficus indica) and ice plant (Mesembryanthemum crystallinum) on human skin fibroblasts and keratinocytes

Immediate and long-term effects of polysaccharides-based formulations on human skin

Extracellular Signal-Regulated Kinase Is a Major Enzyme in Korean Mistletoe Lectin-Mediated Regulation of Macrophage Functions

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