Studies on Span based Soy-bigels with HPMC

Mukherjee, Shubham; Ash, Dipanjana; Majee, Sutapa Biswas; Biswas, Gopa Roy

doi:10.5958/0974-360x.2020.00071.2

Cited by 7 publications

(2 citation statements)

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“…Pure CLX indicated characteristic bands at 3333.13 and 3228.15 cm −1 , which are assigned to SO2NH2 stretching vibrations [49]. The FTIR spectra of span 40 showed a characteristic broad peak of O-H stretching at 3366 cm −1 as well as another peak at 1732 cm −1 of C=O stretching (ester) [50]. While cetyl alcohol revealed bands at 3322, 2915 and 2849 cm −1 of O-H stretch, CH stretch and CH2, respectively [51].…”

Section: Fourier Transform Infrared (Ft-ir) Spectroscopymentioning

confidence: 99%

Celecoxib Loaded In-Situ Provesicular Powder and Its In-Vitro Cytotoxic Effect for Cancer Therapy: Fabrication, Characterization, Optimization and Pharmacokinetic Evaluation

et al. 2020

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Introduction: Several recent studies have shown that the role of cyclooxygenase 2 (COX-2) in carcinogenesis has become more evident. It affects angiogenesis, apoptosis, and invasion, and plays a key role in the production of carcinogens. It has also been reported that COX-2 inhibitors such as celecoxib (CLX) might play an effective role in preventing cancer formation and progression. Formulation of CLX into nanovesicles is a promising technique to improve its bioavailability and anticancer efficacy. Aim: The aim of this study is to optimize and evaluate the anticancer efficacy of CLX-loaded in-situ provesicular powder composed of surfactants and fatty alcohol-based novel nanovesicles in-vitro and determine its pharmacokinetic parameters in-vivo. Methods: The novel provesicular powders were prepared by the slurry method and optimized by 32 full factorial design using the desirability function. Results: Small mean particle size was achieved by the formed vesicles with value of 351.7 ± 1.76 nm and high entrapment efficacy of CLX in the formed vesicles of 97.53 ± 0.84%. Solid state characterization of the optimized formulation showed that the powder was free flowing, showed no incompatibilities between drug and excipients and showed smooth texture. The cytotoxic study of the optimized formula on HCT-116, HepG-2, A-549, PC-3 and MCF-7 cell lines showed significant increase in activity of CLX compared to its free form. The pharmacokinetic study on albino rabbits after oral administration showed significant increase in the area under the curve (AUC)0–24 h and significantly higher oral relative bioavailability of the optimized formulation compared to Celebrex® 100 mg market product (p < 0.05). Conclusion: All findings of this study suggest the potential improvement of efficacy and bioavailability of CLX when formulated in the form of in-situ provesicular powder composed of surfactants and fatty alcohol-based novel nanovesicles for its repositioned use as an anticancer agent.

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Section: Fourier Transform Infrared (Ft-ir) Spectroscopymentioning

confidence: 99%

Celecoxib Loaded In-Situ Provesicular Powder and Its In-Vitro Cytotoxic Effect for Cancer Therapy: Fabrication, Characterization, Optimization and Pharmacokinetic Evaluation

et al. 2020

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“…On the basis of polarity of the solvents gels are categories into different types organogel (Nonpolar solvent), hydrogel (Polar solvent). Some new gels have also been reported such as emulgels and bi-gels [2]. They have good water content present in their structure providing hydration of stratum corneum.…”

Section: Introductionmentioning

confidence: 99%

Bi-Gels: A Novel Material for Transdermal Drug Delivery

2021

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Bi-gels semi solid formulation is combination of organogel and hydrogel with better application property such as pharmaceutical and cosmetics. The main objective of this review is specially focuses on application of bi-gels as drug delivery vehicles by transdermal route. It contains two different phases which are polar and nonpolar due to which, it possess some significant features such as ability to deliver the hydrophilic and hydrophobic drugs which also have improved permeability of drugs, better spreading ability, and water wash ability. Hence, bigels have both organogels and hydrogels they can enhanced hydration of stratum corneum and also had an ability to manipulate the drug release rate from the dosage from.

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