Studies on the active center of monoamine oxidase

Amphetamine, Diethylpropion and Tranylcypromin, a Psychopharmacological Study in the Relation between Structure and Activity

“…The non-proprietary generic name adopted in U.S.A. (and the U.K.) for this compound is tranylcypromin. It is also known as SKF 3852).The properties of tranylcypromin have been described by COSTA et al a and b, 1960) and by ZELLER (1960). There seems to exist a principal difference in mode of action between the hydrazide type compounds and tranylcypromin, in that the hydrazides inhibits the MAO, whereas tranylcypromin competes with the natural substrate for MAO.…”

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The chance observation, made during clinical work on the tuberculostatic activity of iproniazid, that the compound had a "mood elevating" effect led to intensive experimental studies, expecially by Zeller and his group, recently reviewed by ZELLER (1960). They found iproniazid to be a potent inhibitor of mono-amine oxidase (MAO).

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