Studies on the Administration, Absorption, Distribution and Excretion of Aureomycin in Children

Abstract

Data are presented on the administration, absorption, distribution and excretion of aureomycin in children. From these data, tentative oral and intravenous dosage schedules of, respectively, 11 mg./kg. body weight every 4 hours and 6.6 mg./kg. body weight every 12 hours are proposed. The same total daily oral dose (60 mg./kg. body weight) divided into less frequent individual doses than every four hours might prove equally effective and well tolerated. The possibility of uptake of aureomycin by some or all the cells of the human body is also suggested. The observation of apparent photosensitivity occurring during aureomycin ingestion is reported.