Studies on the Anti-inflammatory potential of selected medicinal plants <i>in vitro</i>

Inflammation is the host's protective response to any stimulus that harms the body. Excessive inflammatory process causes tissue damage. Therefore, an anti-inflammatory agent is needed. The use of natural ingredients, especially sea sponges, is an option to reduce the side effects of anti-inflammatory agents. This utilization is related to the discovery of new agents. So, we tested the effect of the ethanol extract of Petrosia sp. as an anti-inflammatory agent. Animal induced with 1% carrageenan and left for 1 hour. After that the animals were divided into 6 groups (n = 4) and given oral treatment, namely: Group I (normal group); Group II (negative group); Group III (ethanol extract of Petrosia sp. Concentration of 0.05mg/ml); Group IV (ethanol extract of Petrosia sp. Concentration 0.1mg/ml); Group V (ethanol extract of Petrosia sp. Concentration 0.2mg/ml); and Group VI (positive group, Diclofenac Sodium). After 1 hour, the animals were measured for edema volume and plasma TNF-α levels. Based on the research conducted, the ethanol extract of Petrosia sp. decreased edema volume and plasma TNF-α levels in inflammatory mice. The concentration of 0.2mg/mL had a significant effect on the negative control used (p <0.05). On the other hand, Petrosia sp. indicates the presence of alkaloids, flavonoids, and steroids. They may play an important role in the anti-inflammatory process. Thus, it can be concluded that the ethanol extract of Petrosia sp. has anti-inflammatory activity.

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Anti-Inflammatory Activity of Ethanol Extract of Marine Sponge Petrosia Sp. by Supression the Level of Tumor Necrosis Factor-alpha

Fristiohady

Malaka

Safitri

et al. 2021

RJPT

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Synthesis of New Iron Nanoparticles derived from Beta Vulgaris Extract and its Bioactivity against Enterobacter cloacae, Anti-inflammatory and House Fly

Hameed

Mohammad

Ahmed

et al. 2021

RJPT

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Objective: This study aimed to synthesize a new iron nanoparticles derived from beta vulgaris extract and test its bioactivity against certain microbes. Materials and Methods: preparation of extract and the nanoparticles were done using certain procedures, while the Identification of Entero cloacae VITEK-2 ID-GN and AST-N 020 cards correspondingly applied for detection and susceptibility tests direct as of positive BacT/ALERT FA and FN blood cultures. Antibiotic susceptibility testing and anti bacterial as well as anti inflammatory activity, inhibition of protein denaturation and anti oxidant efficiency were achieved using AFM, UV-Visible and other instruments. Results: the presence of antioxidants, antibacterial and anti-inflammatory materials in nanoparticles were much more than in the extract. Conclusions: iron nanoparticles show much more activity against bacteria, oxidant and inflammatory agents.

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Evaluation of Antihyperlipidemic activity of leaves of Cassia tora

Obilineni

Latha

Srikala

et al. 2022

RJPT

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Aim: To evaluate the antihyperlipidemic activity of leaves of cassia tora Objective: Hyperlipidemia is a clinical condition causing lethal diseases like atherosclerosis, myocardial infarction etc that ultimately leads to death. Several works have been reported that the extracts of many plants have antihyperlipidemic activity. Cassia tora is used for a long time as a daily vegetable in many countries. It consists of phytochemical constituents like flavonoids which lowers blood cholesterol level. Materials and Methods: Materials used: Antihyperlipidemic activity of Cassia tora was screened by a model, Cholesterol diet induced hyperlipidemia. Marker enzymes like LDH, LDL, VLDL, total protein, total cholesterol, AST, ALP, ALT,SOD, Catalase, LPO and histopathology of myocardium and aorta carried out. Results: Flavonoids of leaves of Cassia tora treated group showed significant decrease in LDL-Cholesterol, total cholesterol, triglycerides, AST, ALT, ALP and increase in HDL cholesterol, albumin, total protein and further was concluded by histopathological studies. Conclusion: From result, it was concluded that flavonoid of leaves of Cassia tora shows antihyperlipidemic activity in the heart of rats.

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Studies on the Anti-inflammatory potential of selected medicinal plants in vitro

Cited by 5 publications

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Anti-Inflammatory Activity of Ethanol Extract of Marine Sponge Petrosia Sp. by Supression the Level of Tumor Necrosis Factor-alpha

Anti-Inflammatory Activity of Ethanol Extract of Marine Sponge Petrosia Sp. by Supression the Level of Tumor Necrosis Factor-alpha

Synthesis of New Iron Nanoparticles derived from Beta Vulgaris Extract and its Bioactivity against Enterobacter cloacae, Anti-inflammatory and House Fly

Evaluation of Antihyperlipidemic activity of leaves of Cassia tora

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