Studies on the Antioxidant and Free Radical Scavenging Properties of Idb 1016 A New Flavanolignan Complex

Comoglio, Adriana; Leonarduzzi, Gabriella; Carini, Rita; Busolin, D; Başağa, Hüveyda; Albano, Emanuele; Tomasi, Aldo; Poli, G.; Morazzoni, P.; Magistretti, M

doi:10.3109/10715769009109673

Cited by 62 publications

(33 citation statements)

References 13 publications

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“…The protective activity of silipide against the liver damage induced by CCl4, ethanol and paracetamol could be related to its antioxidant property and inhibit ing effect on membrane lipid peroxidation, believed to be involved in the damaging effect of the three xeno biotics used (6,(19)(20)(21). Comoglio et al (22) recently reported that silipide given by the oral route to rats antagonized the lipid peroxidation induced in liver microsomes by NADPH, CCIa and cumene hydroperox ide and acted as an effective free radical scavenger to wards different types of radical species. Also the activ ity against liver injury induced by galactosamine, which produces a damage similar to that observed in human hepatitis (23,24), partly can be ascribed to the same mechanism of action.…”

Section: Discussionmentioning

confidence: 99%

Protective Activity of Silipide on Liver Damage in Rodents

Conti

Malandrino

Magistretti

1992

Japanese Journal of Pharmacology

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ABSTRACT-The activity of silipide, a silybin-phosphatidylcholine complex (IdB 1016), was tested in different models of liver damage in rodents. After oral administration, silipide exhibited a significant and dose-related protective effect against the hepatotoxicity induced by CC14, praseodymium, ethanol and galactosamine. The ED50 values for inhibition of the rise in ASAT and ALAT levels caused by CC14 and praseodymium and for antagonism of the increase in liver triglycerides caused by ethanol ranged from 93 to 156 mg/kg (as silybin). At a dose of 400 mg/kg (as silybin), silipide was also active in protecting against paracetamol-induced hepatotoxicity. Silybin and phosphatidylcholine at doses equivalent to those contained in the active doses of silipide failed to show any significant protective activity in these models. The liver protective effect of silipide is probably related to its antioxidant activ ities and to a stimulating effect on the hepatic synthesis of RNA and proteins.

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Section: Discussionmentioning

confidence: 99%

Protective Activity of Silipide on Liver Damage in Rodents

Conti

Malandrino

Magistretti

1992

Japanese Journal of Pharmacology

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“…This dose is similar to high doses employed in clinical trials (9,10). Appearance and weight of the mice were checked on a weekly basis.…”

Section: Animal Experiments and Dosingmentioning

confidence: 99%

Phytoestrogens and xenoestrogens: The contribution of diet and environment to endocrine disruption

Waring

Ayers

Gescher

et al. 2008

The Journal of Steroid Biochemistry and Molecular Biology

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“…4 Silymarin protects experimental animals against the hepatotoxin ␣-amanitin 2 and has a strong antioxidant property. 5 Other biologic properties of silymarin and its components have been reported, including inhibition of LOX 6 and PG synthetase. 7 For over 20 years, silymarin has been used clinically in Europe for the treatment of alcoholic liver disease and as an antihepatotoxic agent.…”

mentioning

confidence: 99%

“…8 As a therapeutic agent, it is well tolerated and largely free of adverse effects. 5 It might be a potent anticarcinogen against in vitro 9 and in vivo 10,11 carcinogenesis. However, animal chemopreventive studies have been mainly limited to skin, 11,12 and only few studies have involved the digestive organs, including colon.…”

mentioning

confidence: 99%

Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane‐induced colon carcinogenesis in male F344 rats

Kohno

Tanaka

Kawabata

et al. 2002

Intl Journal of Cancer

135

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The modifying effect of dietary administration of the polyphenolic antioxidant flavonoid silymarin, isolated from milk thistle [Silybum marianum (L.) Gaertneri], on AOM-induced colon carcinogenesis was investigated in male F344 rats. In the short-term study, the effects of silymarin on the development of AOM-induced colonic ACF, being putative precursor lesions for colonic adenocarcinoma, were assayed to predict the modifying effects of dietary silymarin on colon tumorigenesis. Also, the activity of detoxifying enzymes (GST and QR) in liver and colonic mucosa was determined in rats gavaged with silymarin. Subsequently, the possible inhibitory effects of dietary feeding of silymarin on AOM-induced colon carcinogenesis were evaluated using a long-term animal experiment. In the short-term study, dietary administration of silymarin (100, 500 and 1,000 ppm in diet), either during or after carcinogen exposure, for 4 weeks caused significant reduction in the frequency of colonic ACF in a dose-dependent manner. Silymarin given by gavage elevated the activity of detoxifying enzymes in both organs. In the long-term experiment, dietary feeding of silymarin (100 and 500 ppm) during the initiation or postinitiation phase of AOM-induced colon carcinogenesis reduced the incidence and multiplicity of colonic adenocarcinoma. The inhibition by feeding with 500 ppm silymarin was significant (p < 0.05 by initiation feeding and p < 0.01 by postinitiation feeding). Also, silymarin administration in the diet lowered the PCNA labeling index and increased the number of apoptotic cells in adenocarcinoma. ␤-Glucuronidase activity, PGE 2 level and polyamine content were decreased in colonic mucosa. These results clearly indicate a chemopreventive ability of dietary silymarin against chemically induced colon tumorigenesis and will provide a scientific basis for progression to clinical trials of the chemoprevention of human colon cancer. Colorectal cancer is the third most common malignant neoplasm in the world. 1 In Japan, its incidence has been increasing, and it is now the third leading cause of cancer death. In this context, primary prevention, including chemoprevention, is important.Silymarin, the collective name for an extract from milk thistle [Silybum marianum (L.) Gaertneri], 2 is a naturally occurring polyphenolic flavonoid antioxidant. 3 It is composed mainly (-80%, w/w) of silybin (also called silybinin, silibin or silibinin), with smaller amounts of other stereoisomers, such as isosilybin, dihydrosilybin, silydianin and silychristin. 4 Silymarin protects experimental animals against the hepatotoxin ␣-amanitin 2 and has a strong antioxidant property. 5 Other biologic properties of silymarin and its components have been reported, including inhibition of LOX 6 and PG synthetase. 7 For over 20 years, silymarin has been used clinically in Europe for the treatment of alcoholic liver disease and as an antihepatotoxic agent. 8 As a therapeutic agent, it is well tolerated and largely free of adverse effects. 5 It might be a potent antica...

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Studies on the Antioxidant and Free Radical Scavenging Properties of Idb 1016 A New Flavanolignan Complex

Cited by 62 publications

References 13 publications

Protective Activity of Silipide on Liver Damage in Rodents

Protective Activity of Silipide on Liver Damage in Rodents

Phytoestrogens and xenoestrogens: The contribution of diet and environment to endocrine disruption

Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane‐induced colon carcinogenesis in male F344 rats

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