Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and a probable radioprotector

Naik, Gaurav; Priyadarsini, K. Indira; Naik, D.B.; Gangabhagirathi, R.; Mohan, Hari

doi:10.1016/j.phymed.2003.08.001

Cited by 128 publications

(86 citation statements)

References 25 publications

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“…Gamma radiation induced strand breaks formation in plasmid PBR322 DNA was inhibited by aquesous extract of T. chebula [25] . The administration of aqueous extract of T. chebula prior to whole body irradiation of mice resulted in a reduction of peroxidation of membrane lipids in the mice liver as well as a decrease in radiation induced damage to DNA.…”

Section: Antimutagenic Radioprotective and Chemopreventive Activitymentioning

confidence: 94%

“…Aqueous extract of T. chebula inhibited xanthine/xanthine oxidase activity and was also an excellent scavenger of DPPH radicals [25] . T. chebula in a polyherbal formulation (Aller-7/ NR-A2) inhibited free radical induced hemolysis and also significantly inhibited nitric oxide release from lipopolysaccharide stimulated murine macrophages [26] .…”

Section: Antioxidant and Free Radical Scavenging Activitymentioning

confidence: 95%

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The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Bag

Bhattacharyya

Chattopadhyay

2013

Asian Pacific Journal of Tropical Biomedicine

262

180

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Section: Antimutagenic Radioprotective and Chemopreventive Activitymentioning

confidence: 94%

Section: Antioxidant and Free Radical Scavenging Activitymentioning

confidence: 95%

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Bag

Bhattacharyya

Chattopadhyay

2013

Asian Pacific Journal of Tropical Biomedicine

262

180

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“…The leaves, bark and fruit of T. chebula possessed high anti oxidant activity due to the presence of phenolics which is responsible for this activity. 5 Aqueous form of the extract of T. chebula inhibited xanthine/xanthine oxidase activity and was also a scavenger of DPPH radicals. 5 The poly herbal formulation of T. chebula (Aller 7/ NR A2) is found to inhibit the hemolysis and makes the lipopolysaccharide to release nitric oxide in an inhibited form.…”

Section: Anti-oxidant and Free Radical Scavenging Activitymentioning

confidence: 95%

“…5 Aqueous form of the extract of T. chebula inhibited xanthine/xanthine oxidase activity and was also a scavenger of DPPH radicals. 5 The poly herbal formulation of T. chebula (Aller 7/ NR A2) is found to inhibit the hemolysis and makes the lipopolysaccharide to release nitric oxide in an inhibited form. 6 Acetone extract has stronger anti oxidant activity than alpha tocopherol and HPLC analysis with diode array detection indicated the presence of phenolic compounds such as hydroxybenzoic acid derivatives, hydroxyl cinnamic acid derivatives, flavonol aglycones and their glycosides.…”

Section: Anti-oxidant and Free Radical Scavenging Activitymentioning

confidence: 95%

Phytopharmacological overview of Terminalia chebula Retz

Hedina¹,

Kotti²,

Kausar³

et al. 2016

Phcogj

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Phytotherapy is the traditional method used to cure many diseases. Various medicinal plants found in many parts of India are well known for their various medicinal values. The Terminalia chebula Retz. a native plant of Asia is found to have various properties like anti-oxidant and free radical scavenging activity, anti-carcinogenic activity, ant-imutagenic activity, anti-bacterial activity, anti-fungal activity, anti-viral activity, anti-diabetic, renoprotective activity, cardio-protective activity, anti-inflammatory and anti-arthritic activity. These properties of T. chebula discussed in this review are mainly due to the presence of various types of phytoconstituents.

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“…TC belongs to the family Combretaceae and is found throughout India, especially in deciduous forests and areas of light rainfall [13]. In Tibet, due to its astonishing wound healing property, it is entitled as "the king of medicines".…”

Section: Introductionmentioning

confidence: 99%

Enhancement of in Vitro Antioxidant Potential of Terminalia Chebula by Various Fruit Extracts and Optimization of Concentration by Response Surface Methodology

Sharma¹,

Sharma²,

Mishra³

2018

Asian J Pharm Clin Res

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Objective: The main objective of this study was to determine the enhancement of in vitro antioxidant potential of fruits of Terminalia chebula (TC) when used in combination with fruit extracts of Phyllanthus emblica, Ananas comosus, and Punica granatum. Hydroxyl (OH) radical scavenging and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays were used to analyze the antioxidant potential. Method:Formulations of different combinatorial concentrations of fruits to prepare a mixture were achieved with central composite design through response surface methodology. Screening of 300 different combinations of various concentrations was done through hydroxyl radical scavenging assay followed by statistical analysis of data. Further validation of results was done by measuring the antioxidant potential of most bioactive extracts by DPPH method.Results: Screening of 300 samples of different combinations for antioxidant potential revealed the samples with highest percentage inhibition in aqueous (85.2%), ethanolic (92.9%), and aqueous-ethanolic (84.21%) extracts. Data were subjected to analysis of variance and generated a threedimensional response surface plot for highest activity. Further subjecting these extracts to DPPH assay revealed a significant enhancement in the antioxidant potential of ethanolic extract of TC when used in mixture with other plants.Conclusion: Antioxidant activity of TC was enhanced when used in combination with other fruits extracts. These synergistic studies generating valuable interactions between various phytochemicals could lead to a momentous increase in other associated activities to fight against diseases such as cancer and cardiovascular disorders. Further research on isolation of bioactive compounds in the mixture and their potential to fight various types of cancer could lead to a significant augmentation in the activity of natural compounds.

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Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and a probable radioprotector

Cited by 128 publications

References 25 publications

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Phytopharmacological overview of Terminalia chebula Retz

Enhancement of in Vitro Antioxidant Potential of Terminalia Chebula by Various Fruit Extracts and Optimization of Concentration by Response Surface Methodology

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