Studies on the Chinese Crude Drug "Forsythiae Fructus." I. On the Constituents of Forsythiae Fructus on the Market

Nishibe, Sansei; Chiba, Mariko; Hisada, Sueo

doi:10.1248/yakushi1947.97.10_1134

Cited by 20 publications

(9 citation statements)

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“…Addition of as much as 20% (v/v) methanol enabled extraction of arctigenin in amounts up to 902. 4• ixg g 1, approximately 10% higher than that of methanol extraction. In addition to improving the extraction yield SFE with carbon dioxide-methanol, 80:20, selectively extracted arctigenin, because the extraction yields of the other constituents, e.g.…”

Section: Hplc-esi-ms-ms Analysis Of the Extract Obtained From The Frumentioning

confidence: 88%

High performance liquid chromatography-electrospray lonization MS-MS analysis ofForsythia koreana fruits, leaves, and stems. Enhancement of the efficiency of extraction of arctigenin by use of supercritical-fluid extraction

2003

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SummaryA method involving high-performance liquid chromatography coupled with eJectrospray MS-MS has been developed for the analysis of the constituents of the fruits, leaves, and stems of Forsythia koreana. Ten compounds including caffeoyl glycosides and hgnans could be separated and detected with good sensitivity. The MS-MS spectra obtained provided information about their structures, for example the sugar and aglycone moieties present. Supercritical-fluid extraction was also used to improve the efficiency of extraction of arctigenin, which has the highest anti-inflammatory activity of the compounds produced by this plant. Although carbon dioxide without any modifier extracted only 66% of that obtained by extraction with methanol, an 80:20 (v/v) carbon dioxide-methanol mixture greatly enhanced the extraction yieldto 110%.

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Section: Hplc-esi-ms-ms Analysis Of the Extract Obtained From The Frumentioning

confidence: 88%

High performance liquid chromatography-electrospray lonization MS-MS analysis ofForsythia koreana fruits, leaves, and stems. Enhancement of the efficiency of extraction of arctigenin by use of supercritical-fluid extraction

2003

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“…Oleaceae Forsythiae Fructus (known in Korea as Yeon-gyo) containing triterpenoids, lignans and its glycosides (Nishibe et al, 1977;Chiba et al, 1978Chiba et al, , 1979, is a traditional herbal medicine used as an anti-inflammatory, diuretics, antidotes, and antibacterials in Korea, China, and Japan (Lee et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activity of arctigenin from Forsythiae Fructus

Kang

Lee

Kim

2008

Journal of Ethnopharmacology

128

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“…Forsythiae fructus (FF), the dried fruits of Forsythia viridissima LINDLE (Oleaceae), which are known as Yeon Kyo in Korea, had been reported to have the anti-inflammatory ingredients such as triterpenoids, lignans, flavonoids, and their glycosides, 6,7) and so are used as a herbal medicine due to their anti-inflammatory, diuretic, antidote, extrusion of pus, and antibacterial effects in Korea, China, and Japan. 8) In a previous study, we found that the natural lignans and flavonoids of FF inhibit inflammatory and asthmatic responses.…”

Section: )mentioning

confidence: 99%

Effects of Hydroxy Pentacyclic Triterpene Acids from Forsythia viridissima on Asthmatic Responses to Ovalbumin Challenge in Conscious Guinea Pigs

Lee

Moon

Kim

2010

Biological & Pharmaceutical Bulletin

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Bronchial asthma is considered to be a chronic inflammatory disease of the airways. Thus, anti-inflammatory therapy is considered central for its long-term asthma management. 1)Inhaled corticosteroids are highly effective chronic treatments, and are capable of suppressing the underlying inflammatory process. Furthermore, combination inhalers containing corticosteroids and long-acting b 2 -agonists are the principle approach to asthma therapy, and are being increasingly used in patients with persistent symptoms.2-3) However, concern persists regarding the use of inhaled corticosteroids, because the fear is irrational long-term side effects, such as, osteoporosis and growth stunting in children.3) Although these effective medications are delivered by inhalation, compliance is surprisingly poor.3,4) But dichromone flavonoid derivative, cromolyn sodium (CRO), which is a similar chemical structure to flavonoids, inhibits the release of chemical mediators, and has been used as anti-asthmatic agent, especially the prophylactic treatment of both allergic and exercise-induced asthma via the first dry-powder inhaler. 5)Forsythiae fructus (FF), the dried fruits of Forsythia viridissima LINDLE (Oleaceae), which are known as Yeon Kyo in Korea, had been reported to have the anti-inflammatory ingredients such as triterpenoids, lignans, flavonoids, and their glycosides, 6,7) and so are used as a herbal medicine due to their anti-inflammatory, diuretic, antidote, extrusion of pus, and antibacterial effects in Korea, China, and Japan. 8) In a previous study, we found that the natural lignans and flavonoids of FF inhibit inflammatory and asthmatic responses. 9,10) In the present study, we isolated three hydroxyl pentacyclic triterpene acids (HTAs), namely, oleanolic acid (OA), ursolic acid (UA), and betulinic acid (BA), from an ethylacetate fraction of FF, and sought to determine their effects and the underlying mechanisms involved on immunoglobulin E (IgE)-mediated asthmatic response induced by an aerosolized ovalbumin (AOVA) challenge in ovalbumin-sensitized guinea pigs. Their anti-asthmatic effects, which were investigated by measuring sRaw during immediate-phase response (IAR) and late-phase response (LAR) in a double-chambered plethysmograph, [10][11][12] were compared with those elicited by the authorized anti-asthmatic drugs, salbutamol (SAL), dexamethasone (DEX), and CRO. In addition, the chemical mediators of inflammation, histamine, eosinophil peroxidase (EPO), phospholipase A 2 (PLA 2 ), and leukocytosis, were quantified in bronchoalveolar lavage fluid (BALF), and accompanying histopathological changes in lung tissues were monitored. For the identification of anti-inflammatory ingredients from Forsythiae fructus (FF), we isolated three hydroxyl pentacyclic triterpene acids (HTAs), namely, oleanolic acid, ursolic acid, and betulinic acid, from an ethylacetate fraction of FF, and evaluated the effect of these triterpene acids on asthmatic guinea pigs by measuring specific airway resistance (sRaw) during both immediate-pha...

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Studies on the Chinese Crude Drug "Forsythiae Fructus." I. On the Constituents of Forsythiae Fructus on the Market

Cited by 20 publications

References 0 publications

High performance liquid chromatography-electrospray lonization MS-MS analysis ofForsythia koreana fruits, leaves, and stems. Enhancement of the efficiency of extraction of arctigenin by use of supercritical-fluid extraction

High performance liquid chromatography-electrospray lonization MS-MS analysis ofForsythia koreana fruits, leaves, and stems. Enhancement of the efficiency of extraction of arctigenin by use of supercritical-fluid extraction

Anti-inflammatory activity of arctigenin from Forsythiae Fructus

Effects of Hydroxy Pentacyclic Triterpene Acids from Forsythia viridissima on Asthmatic Responses to Ovalbumin Challenge in Conscious Guinea Pigs

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