Studies on the curcumin phospholipid complex solidified with Soluplus®

Wang, Jianan; Wang, Lulu; Zhang, Lan; He, Dandan; Ju, Jianming; Li, Weiguang

doi:10.1111/jphp.12857

Cited by 22 publications

(10 citation statements)

References 23 publications

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“…A different result was shown by F3, whose recognizable peak of CUR was still observed. The disappearance of CUR peaks in F1, F2 and F4 indicated the miscibility among components and transformation of CUR into an amorphous state [39,40]. The CUR might have been homogeneously distributed in the polymeric matrix.…”

Section: Thermal Propertiesmentioning

confidence: 99%

Curcumin Micelles Entrapped in Eudragit S-100 Matrix: a Synergistic Strategy for Enhanced Oral Delivery

et al. 2021

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Background: Therapeutic activities of curcumin (CUR) via oral administration are hampered by the lack of bioavailability due to its poor water solubility and rapid degradation in GI tract. Materials & methods: This preliminary study developed CUR micelle-eudragit S100 (EUD) dry powder (CM-EDP) spray-dried formulations. Poloxamer 407 was used as a micelle-forming agent and EUD as an entrapping matrix for protection over hydrolysis and enzymes in the GI tract. Results: The morphology of CM-EDP showed agglomeration with cratering on the surface of particles. Differential thermal analysis and x-ray diffractometry data exhibited evidence that CUR was converted into amorphous solid. An increased concentration of micelle-forming and dispersion matrix polymers resulted in a high fraction of drug being converted into the amorphous state. A significant increase in dissolution by 7–10 times was achieved compared with that of raw CUR. Conclusion: The present study disclosed the CM-EDP potency for future development of CUR oral formulation.

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Section: Thermal Propertiesmentioning

confidence: 99%

Curcumin Micelles Entrapped in Eudragit S-100 Matrix: a Synergistic Strategy for Enhanced Oral Delivery

et al. 2021

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“…Curcumin complexed in a phospholipid has been reported to have better bioavailability (125.80%) as compared to conventional curcumin . Encapsulating curcumin in polyvinyl caprolactam–polyvinyl acetate polyethylene glycol graft copolymer solidified powder has been shown to change the state of curcumin from crystalline to amorphous form, due to which its bioavailability improves significantly …”

Section: Pharmacokinetics/bioavailability Of Curcumin: Problems and Pmentioning

confidence: 99%

Benefits of curcumin in brain disorders

et al. 2019

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Curcumin is widely consumed in Asia either as turmeric directly or as one of the culinary ingredients in food recipes. The benefits of curcumin in different organ systems have been reported extensively in several neurological diseases and cancer. Curcumin has got its global recognition because of its strong antioxidant, anti‐inflammatory, anti‐cancer, and antimicrobial activities. Additionally, it is used in diabetes and arthritis as well as in hepatic, renal, and cardiovascular diseases. Recently, there is growing attention on usage of curcumin to prevent or delay the onset of neurodegenerative diseases. This review summarizes available data from several recent studies on curcumin in various neurological diseases such as Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Huntington's disease, Prions disease, stroke, Down's syndrome, autism, Amyotrophic lateral sclerosis, anxiety, depression, and aging. Recent advancements toward increasing the therapeutic efficacy of curcuma/curcumin formulation and the novel delivery strategies employed to overcome its minimal bioavailability and toxicity studies have also been discussed. This review also summarizes the ongoing clinical trials on curcumin for different neurodegenerative diseases and patent details of curcuma/curcumin in India.

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“…In addition, other advantage of the phospholipid complex includes prolonging the half‐life of the drug in vivo . Wang et al . reported that a curcumin–phospholipid complex (CPC) was prepared successfully and solidified with Soluplus (CSP).…”

Section: Introductionmentioning

confidence: 99%

“…[19] In addition, other advantage of the phospholipid complex includes prolonging the half-life of the drug in vivo. [20] Wang et al [21] reported that a curcumin-phospholipid complex (CPC) was prepared successfully and solidified with Soluplus (CSP). The results showed that CSP possessed a markedly increased dissolution rate and an enhancement in pharmacokinetic parameters compared with curcumin and CPC.…”

Section: Introductionmentioning

confidence: 99%

Preparation and preliminary pharmacokinetics study of GNA-loaded zein nanoparticles

Cheng

Wang

Zhang

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Gambogenic acid (GNA), one of the main active ingredients isolated from Garcinia cambogia, has shown diverse antitumour activities. However, short biological half‐life and low oral bioavailability severely limit its clinical application. Here, we developed GNA‐loaded zein nanoparticles (GNA‐ZN‐NPs) based on phospholipid complex and zein nanoparticles to prolong the circulation time and enhance oral bioavailability of GNA. Methods The physicochemical properties of GNA‐ZN‐NP were characterized in details. The in vitro release profile, in vivo pharmacokinetic experiments and tissue distribution of GNA‐ZN‐NPs were also evaluated. Key findings The particle size, PDI and encapsulation efficiency of GNA‐ZN‐NPs were 102.90 nm, 0.027 and 76.35 ± 0.64%, respectively. The results of SEM, FTIR, DSC and XRD demonstrated that GNA‐ZN‐NPs were prepared successfully. The in vitro dissolution of GNA‐ZN‐NPs exhibited controlled release compared with raw GNA solution. The pharmacokinetic study showed that the AUC of GNA‐ZN‐NPs was significantly increased, and the t1/2 and MRT values of GNA‐ZN‐NPs were 3.21‐fold and 2.19‐fold higher than that of GNA solution. Tissue distribution results illustrated that GNA‐ZN‐NPs showed hepatic‐targeting properties. Conclusion GNA‐ZN‐NPs significantly enhanced the oral bioavailability and prolonged half‐life of GNA, providing a promising oral drug delivery system to improve in vivo pharmacokinetic behaviour of GNA.

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Studies on the curcumin phospholipid complex solidified with Soluplus®

Abstract: A simple and convenient solidifying process was used in this study, and the data suggested that this process not only could improve the flowability and dissolution of phospholipid complex, but also increased the oral bioavailability of curcumin.

Cited by 22 publications

References 23 publications

Curcumin Micelles Entrapped in Eudragit S-100 Matrix: a Synergistic Strategy for Enhanced Oral Delivery

Curcumin Micelles Entrapped in Eudragit S-100 Matrix: a Synergistic Strategy for Enhanced Oral Delivery

Benefits of curcumin in brain disorders

Preparation and preliminary pharmacokinetics study of GNA-loaded zein nanoparticles

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