Studies on the cytogenetic and endocrinologic background of spontaneous abortion

Hasegawa, Isao; Tanaka, Keita; Sanada, Hiroyuki; Imai, Tsutomu; Fujimori, R

doi:10.1016/s0015-0282(16)58026-1

Cited by 15 publications

(5 citation statements)

References 14 publications

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“…High follicular luteinizing hormone (LH) levels have been implicated, [54][55][56][57] as well as abnormal progesterone production, 58 increased plasminogen activator inhibitor-1 activity, [59][60][61] higher androgen levels, 47,51,53 reduced glycodelin and insulin-like growth factor binding protein 2 (IGFBP-2), 62 and hyperhomocysteinaemia. 63 It has also been suggested that PCOS is associated with an endometrial inflammatory reaction affecting implantation on the basis of raised levels of C-reactive protein or white cell counts.…”

Section: Early Pregnancymentioning

confidence: 99%

“…High follicular luteinizing hormone (LH) levels have been implicated, 54–57 as well as abnormal progesterone production, 58 increased plasminogen activator inhibitor‐1 activity, 59–61 higher androgen levels, 47,51,53 reduced glycodelin and insulin‐like growth factor binding protein 2 (IGFBP‐2), 62 and hyperhomocysteinaemia 63 …”

Section: Early Pregnancymentioning

confidence: 99%

See 1 more Smart Citation

Polycystic ovary syndrome and pregnancy outcome: red herring or red flag?

Siassakos

Wardle

2007

BJOG

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Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, associated with a characteristic ovarian appearance at ultrasound scan, hyperandrogenism, and ovulatory disorders. The pathogenesis appears to be mainly related to reduced insulin sensitivity in peripheral tissues, leading to hyperinsulinaemia. There is a wide variation in the severity of PCOS symptoms. Women with PCOS are believed to be predisposed to a variety of complications in pregnancy. We present a summary of the evidence surrounding these claims and discuss the weaknesses of the available to date studies.

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Section: Early Pregnancymentioning

confidence: 99%

Section: Early Pregnancymentioning

confidence: 99%

Polycystic ovary syndrome and pregnancy outcome: red herring or red flag?

Siassakos

Wardle

2007

BJOG

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“…However, there is little information in the literature regarding the karyotypes of embryos from PCOS. Hasegawa et al (1996) found that elevated LH and/or polycystic ovary may be involved in the genesis of spontaneous abortions that could not be explained by fetal chromosomal abnormality. However, the 41 patients included were not diagnosed with PCOS because there were no uniform criteria for its diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Early miscarriage rate in lean polycystic ovary syndrome women after euploid embryo transfer – a matched-pair study

Luo

Jie

et al. 2017

Reproductive BioMedicine Online

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The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PCOS is still unknown. In this 1:3 matched-pair study, 67 lean PCOS patients and 201 controls matched for age, body mass index (BMI) and embryo scores undergoing a single euploid blastocyst transfer in vitrified-warmed cycles were analysed. Clinical pregnancy, early miscarriage and live birth rates were compared. Logistic regression analysis was performed to further evaluate the factors associated with early miscarriage and live birth. Clinical pregnancy rates were 50.7% in PCOS and 55.2% in control groups. Early miscarriage rate was significantly (P = 0.029) increased in the PCOS group compared with controls; non-PCOS patients had a significantly higher live birth rate than PCOS patients, P < 0.001. Further regression analyses showed that PCOS was significantly associated with a higher risk of early miscarriage and decreased chance of live birth. In conclusion, PCOS in women undergoing pre-implantation genetic diagnosis may, independently from BMI and karyotype, increase the risk of miscarriage.

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“…In diesem Zusammenhang konnten Hasegawa et al (1996) zeigen, daû Frauen mit einem chromosomal unauffälligen Abort signifikant häufiger Störungen in der Regelanamnese aufwiesen als Frauen mit chromosomal auffälligem Abort. Die Autoren fanden bei diesen Frauen signifikant häufiger polyzystische Ovarien.…”

Section: Introductionunclassified

“…Die Autoren fanden bei diesen Frauen signifikant häufiger polyzystische Ovarien. Bei 40±81 % der Frauen mit habituellen Aborten wurden polyzystische Ovarien sowie erhöhte Spiegel des Luteinisierungshormons diagnostiziert (Hasegawa et al 1996). Bei Frauen mit einem chromosomal unauffälligen Abort kann gezielt nach nicht-chromosomalen Ursachen, z.…”

Section: Introductionunclassified