Studies on the Cytotoxic Effects of Extract of Castor Seed(Ricinus communis L.).

Borah, S.P.; Talukdar, Jayanta

doi:10.1508/cytologia.67.235

Cited by 20 publications

(13 citation statements)

References 16 publications

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“…Sodium chloride (NaCl) seems to be a factor in inducing cytokinesis inhibition and/or cell plate formation suppression. Such effects were also reported by multiple authors (Akaneme and Amaefule, 2012;AskinÇelik and Aslant¨urk, 2010;Borah and Talukdar, 2002;G¨om¨urgen et al, 2005). Nuclear lesions may have occurred due to the disintegration of the nuclear material by salt.…”

Section: Discussionsupporting

confidence: 82%

Chromosomal and Nuclear Alterations in the Root Tip Cells of Vicia faba Induced by Sodium Chloride

Souguir

Abd‐Alla

Hörmann

et al. 2018

Water Environment Research

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Despite the well-known toxic effect of chloride sodium (NaCl), only few studies analyze its genotoxic effect on crops. Micronucleus assay is an efficient tool for the measure of chromosomal DNA damages. Based on this test, the effects of salt on micronucleus induction, and on chromosome and nucleus changes, were investigated in Vicia faba root tips treated with NaCl (electrical conductivity = 25 dS/m) during 24 hours. V. faba meristematic cells showed a significant increase in the number of micronuclei compared with the control. Micronucleus size varied from small to large and appeared at different stages of mitosis. Moreover, different chromosomal aberrations like breaks, bridges, rings, vagrant, and lagging chromosomes, were observed in the metaphase, the anaphase, and the telophase. In addition, nuclear alterations in the interphase were characterized by the presence of binucleated cells, strap nuclei with lesions, hyperchromasia, buds, and nuclei with irregular shapes and lesions.

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Section: Discussionsupporting

confidence: 82%

Chromosomal and Nuclear Alterations in the Root Tip Cells of Vicia faba Induced by Sodium Chloride

Souguir

Abd‐Alla

Hörmann

et al. 2018

Water Environment Research

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“…The treatment of A. cepa root tip cells with different concentration of C. cornigera crude water extract (0.1, 0.01 and 0.001 mg/ml), for different exposure times (4, 6 and 12), the resulted data were presented in table (2).…”

Section: Genotoxicity Of Cynara Cornigera Leaves Aqueous Extractmentioning

confidence: 99%

“…with high concentration (stock solution) induce an increase in percentage of abnormalities (51.034 and 44.123 %, respectively) compared to 4hrs of time treatment which was (35.735%). The most common type of physiological abnormalities which appeared in all the concentrations and periods of treatment are given in plate(2) and(3)and chromosomal stickiness at metaphase is more observed in all treatments.Table(2): The effect of Cynara cornigera leaves aqueous extract on Mitotic Index % and of Normal cells% and Abnormal cells% of A. cepa meristematic cells (Group 2). M.I.…”

mentioning

confidence: 99%

Antimitotic and Genotoxicity Effects of Wild Libyan Artichoke Cynara Cornigera Leaves Aqueous Extract

hasham¹,

garabulli²,

shatshat³

2020

EPRA

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Allium cepa root tip cells were used to find out the effect of Cynara cornigera extract on chromosomal structure and behavior during cell division. To measure the mitotic index and chromosome aberration in treated cells. The root meristem cells were treated with different concentrations of Cynara cornigera leaves aqueous extract (0.1, 0.01 and 0.001 mg/ml) for 4, 6 and 12 hours, respectively. The results indicate that aqueous extracts of C. cornigera plant have the ability to decrease the (MI) values with increasing the concentration at (P<0.005). The treatments have caused different kinds of mitotic abnormalities and chromosomal aberrations, such as: Change percentage of mitotic phases, C-metaphase, Stickiness, Disturbed nuclear membrane, Highly condensation of prophase and Accumulation of cell in interphase. KEY WORDS: Bioassay: Cynara cornigera: Leaf extract: Artichoke; Chromosomal aberrations.

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“…According to this hypothesis, only actively dividing cells, i.e., metaphase and anaphase cells, are included in the calculation. This formula (active mitotic index) provides additional information on the percentage of actively dividing cells [56,57]:…”

Section: Mitotic Indexmentioning

confidence: 99%

Cell Division, Cytotoxicity, and the Assays Used in the Detection of Cytotoxicity

İstifli¹,

Hüsunet²,

İla³

2019

Cytotoxicity - Definition, Identification, and Cytotoxic Compounds

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Cell division is a phenomenon that is encountered in all cells in nature. While normal cell division results in proliferation in single-celled organisms, and development and repair in multicellular organisms, aberrant and untimely cell division results in tumor formation. Therefore, the understanding of the cell division is hidden in identifying the details of the molecular mechanisms that govern cellular division at the exact time and under right conditions. Sometimes these molecular mechanisms are distorted by both intrinsic and extracellular factors, and the division process halts or deviates to an abnormal pathway. At this point, it is essential that the abnormal cells are removed from the tissue by an appropriate mechanism. In this context, in this review, general and specific information about cell division and its molecular control mechanisms were discussed, and different types of cell death mechanisms were mentioned accordingly. In addition, chemical, biological, and physical cytotoxic agents that negatively affect cell division and their mechanisms of action are explained. Finally, a brief review of the principles of different cytotoxicity (cell viability and proliferation) test systems has been performed to provide a source of information for investigators who study cell viability, proliferation, or different types of cellular death pathways.

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Studies on the Cytotoxic Effects of Extract of Castor Seed(Ricinus communis L.).

Cited by 20 publications

References 16 publications

Chromosomal and Nuclear Alterations in the Root Tip Cells of Vicia faba Induced by Sodium Chloride

Chromosomal and Nuclear Alterations in the Root Tip Cells of Vicia faba Induced by Sodium Chloride

Antimitotic and Genotoxicity Effects of Wild Libyan Artichoke Cynara Cornigera Leaves Aqueous Extract

Cell Division, Cytotoxicity, and the Assays Used in the Detection of Cytotoxicity

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