Studies on the Effect of Salyrgan on the Absorption of Water and Colloid from Joints.

Abstract

The oncotic pressure of this solution, calculated according to ADAIR (1928) and corrected for temperature (38" C) according t o WELLS et al. (1935), is 270 mm of water. The following formulas have been used: Oncotic pressure of the hemoglobin solution = __ -p (mm of H,o); V -B 100 ___. B = 2.54; p1 = p ; ; t* t and t,: K = 3700; V = Hb conc. in g per cent' absolute temperatures in degrees of C.

The Resistance to Flow of Fluid through Synovial Membranes in Hydrops of Cardiac Origin. The Lack of Influence of Mersalyl

“…The flow-pressure curve was a straight line. Similar findings concerning the resistance to flow of normal and edematous synovial membranes have been reported (EDLUND 1949).…”

“…These values, as well as the pressure level of the breaking point, do not differ significantly from those earlier published (EDLUND 1949). I n twenty-six operated animals with heart failure there was no breaking point in any of the joints investigated.…”

“…The drug abolished the breaking point of the synovial membrane in about 50 per cent of normal animals, resulting in a decreased resistance to flow a t low pressures (EDLUND and LINDERHOLM 1950). It was suggested that most of the extrarenal actions reported might be explained by the spreading-factor activity of these drugs (EDLUND andLINDERHOLM 1949 and1950). The object of the present investigation was to ascertain whether experimental cardiac failure with hydrops causes the same changes in the synovial membrane's resistance to flow as does inflammatory edema (EDLUND 1949).…”

The Effect of Alloxan on the Flow of Fluid through Normal and Injured Synovial Membranes.

“…In the studies presented here we have shown that alloxan causes the breaking-point to disappear when the measurements are made in normal joints and to reappear when they are made in joints subjected to burns. In these respects alloxan has the same effect as desoxycorticosterone acetate (EDLUND et al 1955;EDLUND 1949). Animals subjected to intraarticular burns by the method used here show histologically a slight second-degree burn in the synovial membrane (EDLUND 1949).…”

“…It might be argued that the reappearance of the breaking-point in the burned alloxan animals can be due to causes other than an anti-oedematous effect of the drug, since we have no histological controls for the degree of oedema. The oedematous reaction, however, cannot possibly have been enhanced by alloxan, because even in more pronounced oedema the pressure-flow curve is a single straight line (EDLUND 1949).…”