Studies on the Effect of Sheep Pox Vaccine on the Immune Response of Sheep Vaccinated With Pneumo-4 Vaccine

Abstract

Convincing seroimmunological studies were conducted to explore the influence of sheep pox vaccine on the immune response to pneumo-4 vaccine in vaccinated sheep, when it is administrated before, after and simultaneously. The experiment was conducted on eighteen susceptible sheep divided into 6 equal groups. Groups 1 and 5 were vaccinated with pneumo-4 vaccine and sheep pox vaccine respectively regarded as control vaccinated groups. Sheep pox vaccine was administered simultaneously with pneumo-4 in Group (2), before and after pneumo-4 vaccine in groups (3 and 4) respectively. The sixth group being left as a non-vaccinated control. The developed antibodies against different antigens incorporated in the used vaccines were monitored by using both serum neutralization test (SNT) and ELISA. The results showed that when sheep pox was administered one-week before vaccination with pneumo-4, the highest antibody titres were developed followed by these induced by simultaneous vaccination in group (2). So, the result explores the immunopotentiating effect of sheep pox vaccine on the immune response of sheep to pneumo-4 vaccine specially when it is administered one week before the other vaccine.